Salivary biomarkers of oxidative stress in children with dental caries: Systematic review and meta-analysis

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dc.contributor.authorMartins, Jordana Resende [UNESP]
dc.contributor.authorDíaz-Fabregat, Beatriz [UNESP]
dc.contributor.authorRamírez-Carmona, Wilmer [UNESP]
dc.contributor.authorMonteiro, Douglas Roberto [UNESP]
dc.contributor.authorPessan, Juliano Pelim [UNESP]
dc.contributor.authorAntoniali, Cristina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversity of Western São Paulo (UNOESTE)
dc.date.accessioned2023-03-01T19:56:52Z
dc.date.available2023-03-01T19:56:52Z
dc.date.issued2022-07-01
dc.description.abstractObjective: To assess the relationship between salivary biomarkers of oxidative stress and dental caries in children. Methods: Studies conducted in children up to 12 years old comparing salivary biomarkers of oxidative stress such as malondialdehyde (MDA), superoxide dismutase (SOD), uric acid, and total antioxidant capacity (TAC), considering children with dental caries lesions and caries-free ones were selected. In addition, salivary parameters such as salivary flow, pH, buffering capacity, calcium and total protein levels were evaluated. A systematic literature review was carried out in 8 databases. The standardized mean difference (SMD) was measured using inverse variance as a statistical method and random effects as an analysis model, corresponding to a 95% confidence interval (CI). Results: The TAC levels were higher in children affected by dental caries compared to caries-free ones (control group), regardless of age (SMD 2.66, CI 1.33, 3.98), or gender (SMD 0.98, CI 0.56, 1.39). When adjusted for normalized protein, MDA levels were lower in the dental caries group than in the control group (SMD −16.51, CI −29.02, −4.00), and SOD levels were higher in the dental caries group (SMD 5.09, CI 0.01.10.18). The total protein concentration in saliva of children with dental caries was higher than in the control group, regardless of age (SMD 0.98, CI 0.27, 1.69), or gender (SMD 0.77, CI 0.45, 1.10). The salivary parameters assessed had lower levels in children affected by dental caries (p < 0.05). Conclusions: The levels of oxidative stress biomarkers and salivary parameters are altered in saliva of children with dental caries.en
dc.description.affiliationDepartment of Preventive and Restorative Dentistry São Paulo State University (UNESP) School of Dentistry, SP
dc.description.affiliationPostgraduate Program in Health Sciences University of Western São Paulo (UNOESTE), SP
dc.description.affiliationDepartment of Basic Sciences São Paulo State University (UNESP) School of Dentistry, SP
dc.description.affiliationUnespDepartment of Preventive and Restorative Dentistry São Paulo State University (UNESP) School of Dentistry, SP
dc.description.affiliationUnespDepartment of Basic Sciences São Paulo State University (UNESP) School of Dentistry, SP
dc.identifierhttp://dx.doi.org/10.1016/j.archoralbio.2022.105432
dc.identifier.citationArchives of Oral Biology, v. 139.
dc.identifier.doi10.1016/j.archoralbio.2022.105432
dc.identifier.issn1879-1506
dc.identifier.issn0003-9969
dc.identifier.scopus2-s2.0-85129444393
dc.identifier.urihttp://hdl.handle.net/11449/239996
dc.language.isoeng
dc.relation.ispartofArchives of Oral Biology
dc.sourceScopus
dc.subjectBiomarker
dc.subjectDental caries
dc.subjectOxidative damage
dc.subjectSaliva
dc.subjectSalivary proteins and peptides
dc.titleSalivary biomarkers of oxidative stress in children with dental caries: Systematic review and meta-analysisen
dc.typeResenha

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