Kaurenoic acid and its sodium salt derivative: Antibacterial activity against Porphyromonas gingivalis and their mechanism of action

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dc.contributor.authorMartins, Carlos H.G.
dc.contributor.authorAbrão, Fariza
dc.contributor.authorMoraes, Thaís S.
dc.contributor.authorOliveira, Pollyanna F.
dc.contributor.authorTavares, Denise C.
dc.contributor.authorMagalhães, Lizandra G.
dc.contributor.authorGalvão, Fábio C. [UNESP]
dc.contributor.authorVeneziani, Rodrigo C.S.
dc.contributor.authorAmbrósio, Sérgio R.
dc.contributor.institutionUniversity of Franca - UNIFRAN
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-06T15:24:47Z
dc.date.available2019-10-06T15:24:47Z
dc.date.issued2018-11-01
dc.description.abstractAim: To evaluate the antibacterial activity of 12 kaurane-type diterpenes against a panel of bacteria that cause endodontic infection. Methods & materials: We conducted tests against bacteria in the planktonic or in the sessile mode, cytotoxic assays for the most promising compounds against human normal lung fibroblast cells, and Porphyromonas gingivalis (ATCC 33277) proteomic analysis. Results & conclusion: Kaurenoic acid and its salt exhibited satisfactory antibacterial action against the evaluated bacteria. Proteomic analysis suggested that these compounds might interfere in bacterial metabolism and virulence factor expression. Kaurane-type diterpenes are an important class of natural products and should be considered in the search for new irrigating solutions to treat endodontic infections.en
dc.description.affiliationResearch Laboratory of Applied Microbiology University of Franca - UNIFRAN
dc.description.affiliationLaboratory of Mutagenesis University of Franca - UNIFRAN
dc.description.affiliationNucleus of Research in Sciences and Technology University of Franca - UNIFRAN
dc.description.affiliationDepartment of Biological Sciences São Paulo State University - UNESP
dc.description.affiliationUnespDepartment of Biological Sciences São Paulo State University - UNESP
dc.format.extent1585-1601
dc.identifierhttp://dx.doi.org/10.2217/fmb-2018-0140
dc.identifier.citationFuture Microbiology, v. 13, n. 14, p. 1585-1601, 2018.
dc.identifier.doi10.2217/fmb-2018-0140
dc.identifier.issn1746-0921
dc.identifier.issn1746-0913
dc.identifier.scopus2-s2.0-85056715505
dc.identifier.urihttp://hdl.handle.net/11449/187077
dc.language.isoeng
dc.relation.ispartofFuture Microbiology
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectantibacterial activity
dc.subjectantibiofilm
dc.subjectcytotoxic assay
dc.subjectkaurane-type diterpenes
dc.subjectP. gingivalis
dc.subjectproteomic
dc.titleKaurenoic acid and its sodium salt derivative: Antibacterial activity against Porphyromonas gingivalis and their mechanism of actionen
dc.typeArtigo

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