Photodynamic inactivation of biofilm: Taking a lightly colored approach to stubborn infection

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dc.contributor.authorDe Melo, Wanessa C.M.A.
dc.contributor.authorAvci, Pinar
dc.contributor.authorDe Oliveira, Milene Nóbrega
dc.contributor.authorGupta, Asheesh
dc.contributor.authorVecchio, Daniela
dc.contributor.authorSadasivam, Magesh
dc.contributor.authorChandran, Rakkiyappan
dc.contributor.authorHuang, Ying-Ying
dc.contributor.authorYin, Rui
dc.contributor.authorPerussi, Livia R. [UNESP]
dc.contributor.authorTegos, George P.
dc.contributor.authorPerussi, Janice R.
dc.contributor.authorDai, Tianhong
dc.contributor.authorHamblin, Michael R.
dc.contributor.institutionMassachusetts General Hospital
dc.contributor.institutionHarvard Medical School
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionDefense Institute of Physiology and Allied Sciences
dc.contributor.institutionAmity University
dc.contributor.institutionThird Military Medical University
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity of New Mexico School of Medicine
dc.contributor.institutionUniversity of New Mexico
dc.contributor.institutionHarvard-MIT Division of Health Sciences and Technology
dc.date.accessioned2014-05-27T11:29:52Z
dc.date.available2014-05-27T11:29:52Z
dc.date.issued2013-07-01
dc.description.abstractMicrobial biofilms are responsible for a variety of microbial infections in different parts of the body, such as urinary tract infections, catheter infections, middle-ear infections, gingivitis, caries, periodontitis, orthopedic implants, and so on. The microbial biofilm cells have properties and gene expression patterns distinct from planktonic cells, including phenotypic variations in enzymic activity, cell wall composition and surface structure, which increase the resistance to antibiotics and other antimicrobial treatments. There is consequently an urgent need for new approaches to attack biofilm-associated microorganisms, and antimicrobial photodynamic therapy (aPDT) may be a promising candidate. aPDT involves the combination of a nontoxic dye and low-intensity visible light which, in the presence of oxygen, produces cytotoxic reactive oxygen species. It has been demonstrated that many biofilms are susceptible to aPDT, particularly in dental disease. This review will focus on aspects of aPDT that are designed to increase efficiency against biofilms modalities to enhance penetration of photosensitizer into biofilm, and a combination of aPDT with biofilm-disrupting agents. © 2013 Informa UK Ltd.en
dc.description.affiliationWellman Center for Photomedicine Massachusetts General Hospital, Boston, MA
dc.description.affiliationDepartment of Dermatology Harvard Medical School, Boston, MA
dc.description.affiliationPrograma de Pós-Graduação Interunidades em Bioengenharia-ESC/FMRP/IQSC Universidade de São Paulo, São Carlos, São Paulo
dc.description.affiliationDefense Institute of Physiology and Allied Sciences, Timarpur, Delhi-110 054
dc.description.affiliationAmity Institute of Nanotechnology Amity University, Noida, Uttar Pradesh
dc.description.affiliationDepartment of Dermatology Southwest Hospital Third Military Medical University, Shapingba, Chongqing 400038
dc.description.affiliationUniversidade Estadual Paulista - UNESP, Odontologia, Araraquara, São Paulo
dc.description.affiliationDepartment of Pathology University of New Mexico School of Medicine, Albuquerque, NM 87131
dc.description.affiliationCenter for Molecular Discovery University of New Mexico, Albuquerque, NM
dc.description.affiliationHarvard-MIT Division of Health Sciences and Technology, Cambridge, MA
dc.description.affiliationUnespUniversidade Estadual Paulista - UNESP, Odontologia, Araraquara, São Paulo
dc.format.extent669-693
dc.identifierhttp://dx.doi.org/10.1586/14787210.2013.811861
dc.identifier.citationExpert Review of Anti-Infective Therapy, v. 11, n. 7, p. 669-693, 2013.
dc.identifier.doi10.1586/14787210.2013.811861
dc.identifier.issn1478-7210
dc.identifier.issn1744-8336
dc.identifier.scopus2-s2.0-84880910975
dc.identifier.urihttp://hdl.handle.net/11449/75829
dc.identifier.wosWOS:000323228200006
dc.language.isoeng
dc.relation.ispartofExpert Review of Anti-Infective Therapy
dc.relation.ispartofjcr3.141
dc.relation.ispartofsjr1,264
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectantimicrobial photodynamic therapy
dc.subjectbiofilm
dc.subjectdental infection
dc.subjectextracellular polysaccharide
dc.subjectmicrobial resistance
dc.subjectmultidrug efflux pump
dc.subjectpersister cells
dc.subjectphotosensitizers
dc.subjectazithromycin
dc.subjectchloramphenicol
dc.subjectnanoparticle
dc.subjectantibacterial activity
dc.subjectantibiotic resistance
dc.subjectantifungal activity
dc.subjectbacterial gene
dc.subjectbacterial viability
dc.subjectbacterium adherence
dc.subjectCandida albicans
dc.subjectcell adhesion
dc.subjectcell function
dc.subjectcomplex formation
dc.subjectconfocal laser microscopy
dc.subjectdrug delivery system
dc.subjectenvironmental stress
dc.subjectextracellular matrix
dc.subjecthuman
dc.subjectinterspecific competition
dc.subjectintraspecific competition
dc.subjectmethicillin resistant Staphylococcus aureus infection
dc.subjectmicrobial activity
dc.subjectmicrobial community
dc.subjectnanopharmaceutics
dc.subjectnonhuman
dc.subjectphotodynamic therapy
dc.subjectphotosensitization
dc.subjectProteus mirabilis
dc.subjectPseudomonas aeruginosa
dc.subjectreview
dc.subjectsignal transduction
dc.subjectspecies difference
dc.subjectStaphylococcus epidermidis
dc.subjectstructure analysis
dc.titlePhotodynamic inactivation of biofilm: Taking a lightly colored approach to stubborn infectionen
dc.typeResenha
dcterms.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf

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