Systemic administration of strontium ranelate to enhance the osseointegration of implants: systematic review of animal studies

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dc.contributor.authorScardueli, Cassio Rocha [UNESP]
dc.contributor.authorBizelli-Silveira, Carolina
dc.contributor.authorMarcantonio, Rosemary Adriana C. [UNESP]
dc.contributor.authorMarcantonio, Elcio [UNESP]
dc.contributor.authorStavropoulos, Andreas
dc.contributor.authorSpin-Neto, Rubens
dc.contributor.institutionAarhus Univ
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Malmo
dc.date.accessioned2018-11-29T22:37:38Z
dc.date.available2018-11-29T22:37:38Z
dc.date.issued2018-07-17
dc.description.abstractThe literature states that Strontium (Sr) is able to simultaneously stimulate bone formation and suppress bone resorption. Recent animal studies suggest that the systemic administration of Sr, in the form of strontium ranelate (SRAN), would enhance the osseointegration of implants. The purpose of the present study was to undertake a systematic review on animal studies evaluating the systemic administration of Sr to enhance the osseointegration of titanium implants and the remodeling of bone grafts. The MEDLINE (PubMed) and Scopus bibliographic databases were searched from 1950 to October 2017 for reports on the use of systemic and non-radioactive Sr to enhance the osseointegration of titanium implants and the remodeling of bone grafts in animals. The search strategy was restricted to English language publications using the combined terms: strontium and implant or graft or biomaterial or bone substitute. Five studies were included, all related to the systemic administration of Sr in the form SRAN, and its effects on osseointegration of titanium implants. No studies on the use of SRAN-based therapy to enhance the remodeling of bone grafts were found. The studies differed notably with respect to the study population (healthy female rats, healthy male rats, and female rats with induced osteoporosis) and SRAN dose (ranging from 500 to 1000 mg/kg/day). Results were diverse, but a tendency suggesting positive influence of systemic SRAN administration on the osseointegration of titanium implants was observed. No major side-effects due to strontium administration were reported. Systemic Sr administration, in the form of SRAN, seems to enhance peri-implant bone quality and implant osseointegration in animals, however, at a moderate extent. Further studies, evaluating both the effects of this drug on implant osseointegration and the risk/benefit of its use, are needed to provide a rationale of this therapeutic approach.en
dc.description.affiliationAarhus Univ, Dept Dent & Oral Hlth, Aarhus, Denmark
dc.description.affiliationSao Paulo State Univ Unesp, Sch Dent, Dept Periodontol, Sao Paulo, Brazil
dc.description.affiliationUniv Malmo, Fac Odontol, Dept Periodontol, Malmo, Sweden
dc.description.affiliationUnespSao Paulo State Univ Unesp, Sch Dent, Dept Periodontol, Sao Paulo, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCAPES: 003628/2015-09
dc.format.extent9
dc.identifierhttp://dx.doi.org/10.1186/s40729-018-0132-8
dc.identifier.citationInternational Journal Of Implant Dentistry. Tokyo: Springer Japan Kk, v. 4, 9 p., 2018.
dc.identifier.doi10.1186/s40729-018-0132-8
dc.identifier.fileWOS000439182500001.pdf
dc.identifier.issn2198-4034
dc.identifier.urihttp://hdl.handle.net/11449/166252
dc.identifier.wosWOS:000439182500001
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofInternational Journal Of Implant Dentistry
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectStrontium
dc.subjectSystemic use
dc.subjectOsseointegration
dc.subjectBone remodeling
dc.titleSystemic administration of strontium ranelate to enhance the osseointegration of implants: systematic review of animal studiesen
dc.typeResenha
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer

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