Cannabidiol improves Nile tilapia cichlid fish welfare
dc.contributor.author | Camargo-dos-Santos, Bruno [UNESP] | |
dc.contributor.author | Bellot, Marina Sanson [UNESP] | |
dc.contributor.author | Guermandi, Isabela Inforzato [UNESP] | |
dc.contributor.author | Favero-Neto, João [UNESP] | |
dc.contributor.author | da Silva Rodrigues, Maira [UNESP] | |
dc.contributor.author | da Costa, Daniel Fernandes [UNESP] | |
dc.contributor.author | Nóbrega, Rafael Henrique [UNESP] | |
dc.contributor.author | Filev, Renato | |
dc.contributor.author | Gonçalves-de-Freitas, Eliane [UNESP] | |
dc.contributor.author | Giaquinto, Percília Cardoso [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | |
dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | |
dc.date.accessioned | 2023-07-29T13:25:15Z | |
dc.date.available | 2023-07-29T13:25:15Z | |
dc.date.issued | 2022-12-01 | |
dc.description.abstract | Cannabidiol (CBD) is a substance derived from Cannabis sativa, widely studied in medicine for controlling neural diseases in humans. Besides the positive effects on humans, it also presents anxiolytic proprieties and decreases aggressiveness and stress in mammals. Therefore, CBD has the potential to increase welfare in reared animals, as it seems to reduce negative states commonly experienced in artificial environments. Here, we tested the effect of different CBD doses (0, 1, 10 and 20 mg/kg) on aggressiveness, stress and reproductive development of the Nile tilapia (Oreochromis niloticus) a fish reared worldwide for farming and research purposes. CBD mixed with fish food was offered to isolated fish for 5 weeks. The 10 mg/kg dose decreased fish’s aggressiveness over time, whereas 20 mg/kg attenuated non-social stress. Both doses decreased the baseline cortisol level of fish and increased the gonadosomatic index. However, CBD 1 and 10 mg/kg doses decreased the spermatozoa number. No CBD dose affected feeding ingestion and growth variables, showing that it is not harmful to meat production amount. Despite the effect on spermatozoa, CBD supplementation exhibits high potential to benefit animals’ lives in artificial environments. Therefore, we showed for the first time that CBD could be used as a tool to increase non-mammal welfare, presenting a great potential to be explored in other husbandry and captivity species. | en |
dc.description.affiliation | Department of Structural and Functional Biology Institute of Biosciences of Botucatu São Paulo State University (UNESP), SP | |
dc.description.affiliation | CAUNESP – Aquaculture Center of UNESP São Paulo State University, SP | |
dc.description.affiliation | Reproductive and Molecular Biology Group Department of Structural and Functional Biology Institute of Bioscience São Paulo State University (UNESP), SP | |
dc.description.affiliation | Department of Psychiatry and Medical Psychology Escola Paulista de Medicina Universidade Federal de São Paulo, SP | |
dc.description.affiliation | Departamento de Ciências Biológicas Instituto de Biociências Letras e Ciências Exatas São Paulo State University (UNESP), SP | |
dc.description.affiliationUnesp | Department of Structural and Functional Biology Institute of Biosciences of Botucatu São Paulo State University (UNESP), SP | |
dc.description.affiliationUnesp | CAUNESP – Aquaculture Center of UNESP São Paulo State University, SP | |
dc.description.affiliationUnesp | Reproductive and Molecular Biology Group Department of Structural and Functional Biology Institute of Bioscience São Paulo State University (UNESP), SP | |
dc.description.affiliationUnesp | Departamento de Ciências Biológicas Instituto de Biociências Letras e Ciências Exatas São Paulo State University (UNESP), SP | |
dc.identifier | http://dx.doi.org/10.1038/s41598-022-21759-3 | |
dc.identifier.citation | Scientific Reports, v. 12, n. 1, 2022. | |
dc.identifier.doi | 10.1038/s41598-022-21759-3 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.scopus | 2-s2.0-85140240565 | |
dc.identifier.uri | http://hdl.handle.net/11449/247764 | |
dc.language.iso | eng | |
dc.relation.ispartof | Scientific Reports | |
dc.source | Scopus | |
dc.title | Cannabidiol improves Nile tilapia cichlid fish welfare | en |
dc.type | Artigo |