Cannabidiol improves Nile tilapia cichlid fish welfare

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dc.contributor.authorCamargo-dos-Santos, Bruno [UNESP]
dc.contributor.authorBellot, Marina Sanson [UNESP]
dc.contributor.authorGuermandi, Isabela Inforzato [UNESP]
dc.contributor.authorFavero-Neto, João [UNESP]
dc.contributor.authorda Silva Rodrigues, Maira [UNESP]
dc.contributor.authorda Costa, Daniel Fernandes [UNESP]
dc.contributor.authorNóbrega, Rafael Henrique [UNESP]
dc.contributor.authorFilev, Renato
dc.contributor.authorGonçalves-de-Freitas, Eliane [UNESP]
dc.contributor.authorGiaquinto, Percília Cardoso [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2023-07-29T13:25:15Z
dc.date.available2023-07-29T13:25:15Z
dc.date.issued2022-12-01
dc.description.abstractCannabidiol (CBD) is a substance derived from Cannabis sativa, widely studied in medicine for controlling neural diseases in humans. Besides the positive effects on humans, it also presents anxiolytic proprieties and decreases aggressiveness and stress in mammals. Therefore, CBD has the potential to increase welfare in reared animals, as it seems to reduce negative states commonly experienced in artificial environments. Here, we tested the effect of different CBD doses (0, 1, 10 and 20 mg/kg) on aggressiveness, stress and reproductive development of the Nile tilapia (Oreochromis niloticus) a fish reared worldwide for farming and research purposes. CBD mixed with fish food was offered to isolated fish for 5 weeks. The 10 mg/kg dose decreased fish’s aggressiveness over time, whereas 20 mg/kg attenuated non-social stress. Both doses decreased the baseline cortisol level of fish and increased the gonadosomatic index. However, CBD 1 and 10 mg/kg doses decreased the spermatozoa number. No CBD dose affected feeding ingestion and growth variables, showing that it is not harmful to meat production amount. Despite the effect on spermatozoa, CBD supplementation exhibits high potential to benefit animals’ lives in artificial environments. Therefore, we showed for the first time that CBD could be used as a tool to increase non-mammal welfare, presenting a great potential to be explored in other husbandry and captivity species.en
dc.description.affiliationDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu São Paulo State University (UNESP), SP
dc.description.affiliationCAUNESP – Aquaculture Center of UNESP São Paulo State University, SP
dc.description.affiliationReproductive and Molecular Biology Group Department of Structural and Functional Biology Institute of Bioscience São Paulo State University (UNESP), SP
dc.description.affiliationDepartment of Psychiatry and Medical Psychology Escola Paulista de Medicina Universidade Federal de São Paulo, SP
dc.description.affiliationDepartamento de Ciências Biológicas Instituto de Biociências Letras e Ciências Exatas São Paulo State University (UNESP), SP
dc.description.affiliationUnespDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu São Paulo State University (UNESP), SP
dc.description.affiliationUnespCAUNESP – Aquaculture Center of UNESP São Paulo State University, SP
dc.description.affiliationUnespReproductive and Molecular Biology Group Department of Structural and Functional Biology Institute of Bioscience São Paulo State University (UNESP), SP
dc.description.affiliationUnespDepartamento de Ciências Biológicas Instituto de Biociências Letras e Ciências Exatas São Paulo State University (UNESP), SP
dc.identifierhttp://dx.doi.org/10.1038/s41598-022-21759-3
dc.identifier.citationScientific Reports, v. 12, n. 1, 2022.
dc.identifier.doi10.1038/s41598-022-21759-3
dc.identifier.issn2045-2322
dc.identifier.scopus2-s2.0-85140240565
dc.identifier.urihttp://hdl.handle.net/11449/247764
dc.language.isoeng
dc.relation.ispartofScientific Reports
dc.sourceScopus
dc.titleCannabidiol improves Nile tilapia cichlid fish welfareen
dc.typeArtigo

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Jaboticabal - CAUNESP - Centro de Aquicultura da Unesp
Artigos - Biologia - IBILCE