Potential tuberculostatic agents: Micelle-forming copolymer poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid

dc.contributor.authorSilva, M. [UNESP]
dc.contributor.authorLara, A. S.
dc.contributor.authorLeite, C. Q.F. [UNESP]
dc.contributor.authorFerreira, E. I.
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2022-04-28T18:54:32Z
dc.date.available2022-04-28T18:54:32Z
dc.date.issued2001-07-16
dc.description.abstractWith the objective of obtaining slow-acting isoniazid derivatives, of potential use as chemoprophylactics or chemotherapeutics in tuberculosis, the micelle-forming copolymer of poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid was synthesized. The derivative obtained was found to be active in Mycobacterium tuberculosis culture, with a minimal inhibitory concentration (MIC) 5.6 times lower than that of the tuberculostatic drug.en
dc.description.affiliationFaculdade de Ciências Farmacêuticas Universidade Estadual Paulista, CP502, 14801-902, Araraquara - SP
dc.description.affiliationFaculdade de Ciências Farmacêuticas Universidade de São Paulo, CP 05508-970
dc.description.affiliationUnespFaculdade de Ciências Farmacêuticas Universidade Estadual Paulista, CP502, 14801-902, Araraquara - SP
dc.format.extent189-193
dc.identifierhttp://dx.doi.org/10.1002/1521-4184(200106)334:6<189
dc.identifier.citationArchiv der Pharmazie, v. 334, n. 6, p. 189-193, 2001.
dc.identifier.doi10.1002/1521-4184(200106)334:6<189
dc.identifier.issn0365-6233
dc.identifier.scopus2-s2.0-0034952920
dc.identifier.urihttp://hdl.handle.net/11449/219243
dc.language.isoeng
dc.relation.ispartofArchiv der Pharmazie
dc.sourceScopus
dc.subjectCo-polymer poly(ethylene glycol)-poly(aspartic acid)
dc.subjectIsoniazid
dc.subjectMicelle-forming polymer
dc.subjectPotential tuberculostatic agent
dc.subjectProdrug
dc.titlePotential tuberculostatic agents: Micelle-forming copolymer poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniaziden
dc.typeArtigo

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