Potential tuberculostatic agents: Micelle-forming copolymer poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid
dc.contributor.author | Silva, M. [UNESP] | |
dc.contributor.author | Lara, A. S. | |
dc.contributor.author | Leite, C. Q.F. [UNESP] | |
dc.contributor.author | Ferreira, E. I. | |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | |
dc.contributor.institution | Universidade de São Paulo (USP) | |
dc.date.accessioned | 2022-04-28T18:54:32Z | |
dc.date.available | 2022-04-28T18:54:32Z | |
dc.date.issued | 2001-07-16 | |
dc.description.abstract | With the objective of obtaining slow-acting isoniazid derivatives, of potential use as chemoprophylactics or chemotherapeutics in tuberculosis, the micelle-forming copolymer of poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid was synthesized. The derivative obtained was found to be active in Mycobacterium tuberculosis culture, with a minimal inhibitory concentration (MIC) 5.6 times lower than that of the tuberculostatic drug. | en |
dc.description.affiliation | Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista, CP502, 14801-902, Araraquara - SP | |
dc.description.affiliation | Faculdade de Ciências Farmacêuticas Universidade de São Paulo, CP 05508-970 | |
dc.description.affiliationUnesp | Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista, CP502, 14801-902, Araraquara - SP | |
dc.format.extent | 189-193 | |
dc.identifier | http://dx.doi.org/10.1002/1521-4184(200106)334:6<189 | |
dc.identifier.citation | Archiv der Pharmazie, v. 334, n. 6, p. 189-193, 2001. | |
dc.identifier.doi | 10.1002/1521-4184(200106)334:6<189 | |
dc.identifier.issn | 0365-6233 | |
dc.identifier.scopus | 2-s2.0-0034952920 | |
dc.identifier.uri | http://hdl.handle.net/11449/219243 | |
dc.language.iso | eng | |
dc.relation.ispartof | Archiv der Pharmazie | |
dc.source | Scopus | |
dc.subject | Co-polymer poly(ethylene glycol)-poly(aspartic acid) | |
dc.subject | Isoniazid | |
dc.subject | Micelle-forming polymer | |
dc.subject | Potential tuberculostatic agent | |
dc.subject | Prodrug | |
dc.title | Potential tuberculostatic agents: Micelle-forming copolymer poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid | en |
dc.type | Artigo |