Anatomical features of the urethra and urinary bladder catheterization in female mice and rats. An essential translational tool
Carregando...
Arquivos
Data
2011-11-10
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Tipo
Artigo
Direito de acesso
Acesso aberto![Acesso Aberto](assets/repositorio/images/logo_acesso_aberto_simples.png)
![Acesso Aberto](assets/repositorio/images/logo_acesso_aberto_simples.png)
Resumo
PURPOSE: To present fundamental anatomical aspects and technical skills necessary to urethra and urinary bladder catheterization in female mice and rats. METHODS: Urethral and bladder catheterization has been widely utilized for carcinogenesis and cancer research and still remains very useful in several applications: from toxicological purposes as well as inflammatory and infectious conditions to functional aspects as bladder dynamics and vesicoureteral reflux, among many others. RESULTS: Animal models are in the center of translational research and those involving rodents are the most important nowadays due to several advantages including human reproducibility, easy handling and low cost. CONCLUSIONS: Although technical and anatomical pearls for rodent urethral and bladder access are presented as tackles to the advancement of lower urinary tract preclinical investigation in a broaden sight, restriction to female animals hampers the male microenvironment, demanding future advances.
Descrição
Palavras-chave
Anatomy , Rats , Rodent diseases , Urinary tract , animal anatomy , animal experiment , bladder , bladder catheterization , cancer research , carcinogenesis , cost benefit analysis , female , mouse , nonhuman , rat , toxicity testing , urethra , urethral catheterization , vesicoureteral reflux , Animals , Female , Medical Illustration , Mice , Models, Animal , Reproducibility of Results , Sex Factors , Urethra , Urinary Bladder , Urinary Catheterization
Idioma
Inglês
Como citar
Acta Cirurgica Brasileira, v. 26, n. SUPPL. 2, p. 106-110, 2011.