Morphofunctional Improvement of the Facial Nerve and Muscles with Repair Using Heterologous Fibrin Biopolymer and Photobiomodulation

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dc.contributor.authorBueno, Cleuber Rodrigo de Souza
dc.contributor.authorTonin, Maria Clara Cassola
dc.contributor.authorBuchaim, Daniela Vieira
dc.contributor.authorBarraviera, Benedito [UNESP]
dc.contributor.authorJunior, Rui Seabra Ferreira [UNESP]
dc.contributor.authorSantos, Paulo Sérgio da Silva
dc.contributor.authorReis, Carlos Henrique Bertoni
dc.contributor.authorPastori, Cláudio Maldonado
dc.contributor.authorPereira, Eliana de Souza Bastos Mazuqueli
dc.contributor.authorNogueira, Dayane Maria Braz
dc.contributor.authorCini, Marcelo Augusto
dc.contributor.authorRosa Junior, Geraldo Marco
dc.contributor.authorBuchaim, Rogerio Leone
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversity Center of Adamantina (UNIFAI)
dc.contributor.institutionUniversity of Marilia (UNIMAR
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversity of Marilia (UNIMAR)
dc.contributor.institutionUniversity of West Paulista (UNOESTE)
dc.contributor.institutionFaculty of the Midwest Paulista (FACOP)
dc.date.accessioned2023-07-29T13:57:09Z
dc.date.available2023-07-29T13:57:09Z
dc.date.issued2023-05-01
dc.description.abstractPeripheral nerve injuries impair the patient’s functional capacity, including those occurring in the facial nerve, which require effective medical treatment. Thus, we investigated the use of heterologous fibrin biopolymer (HFB) in the repair of the buccal branch of the facial nerve (BBFN) associated with photobiomodulation (PBM), using a low-level laser (LLLT), analyzing the effects on axons, muscles facials, and functional recovery. This experimental study used twenty-one rats randomly divided into three groups of seven animals, using the BBFN bilaterally (the left nerve was used for LLLT): Control group—normal and laser (CGn and CGl); Denervated group—normal and laser (DGn and DGl); Experimental Repair Group—normal and laser (ERGn and ERGl). The photobiomodulation protocol began in the immediate postoperative period and continued for 5 weeks with a weekly application. After 6 weeks of the experiment, the BBFN and the perioral muscles were collected. A significant difference (p < 0.05) was observed in nerve fiber diameter (7.10 ± 0.25 µm and 8.00 ± 0.36 µm, respectively) and axon diameter (3.31 ± 0.19 µm and 4.07 ± 0.27 µm, respectively) between ERGn and ERGl. In the area of muscle fibers, ERGl was similar to GC. In the functional analysis, the ERGn and the ERGI (4.38 ± 0.10) and the ERGI (4.56 ± 0.11) showed parameters of normality. We show that HFB and PBM had positive effects on the morphological and functional stimulation of the buccal branch of the facial nerve, being an alternative and favorable for the regeneration of severe injuries.en
dc.description.affiliationDepartment of Biological Sciences Bauru School of Dentistry (FOB/USP) University of São Paulo
dc.description.affiliationDentistry School University Center of Adamantina (UNIFAI)
dc.description.affiliationMedical School University Center of Adamantina (UNIFAI)
dc.description.affiliationPostgraduate Program in Structural and Functional Interactions in Rehabilitation Postgraduate Department University of Marilia (UNIMAR
dc.description.affiliationCenter for the Study of Venoms and Venomous Animals (CEVAP) São Paulo State University (Universidade Estadual Paulista UNESP)
dc.description.affiliationGraduate Program in Tropical Diseases Botucatu Medical School (FMB) São Paulo State University (UNESP—Universidade Estadual Paulista)
dc.description.affiliationDepartment of Surgery Stomatology Pathology and Radiology Bauru School of Dentistry University of São Paulo
dc.description.affiliationUNIMAR Beneficent Hospital (HBU) University of Marilia (UNIMAR)
dc.description.affiliationDepartment of Prosthodontics and Periodontics Bauru School of Dentistry (FOB/USP) University of São Paulo
dc.description.affiliationMedical School University of West Paulista (UNOESTE)
dc.description.affiliationDentistry School Faculty of the Midwest Paulista (FACOP)
dc.description.affiliationGraduate Program in Anatomy of Domestic and Wild Animals Faculty of Veterinary Medicine and Animal Science University of São Paulo (FMVZ/USP)
dc.description.affiliationUnespCenter for the Study of Venoms and Venomous Animals (CEVAP) São Paulo State University (Universidade Estadual Paulista UNESP)
dc.description.affiliationUnespGraduate Program in Tropical Diseases Botucatu Medical School (FMB) São Paulo State University (UNESP—Universidade Estadual Paulista)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2021/11936-3
dc.identifierhttp://dx.doi.org/10.3390/ph16050653
dc.identifier.citationPharmaceuticals, v. 16, n. 5, 2023.
dc.identifier.doi10.3390/ph16050653
dc.identifier.issn1424-8247
dc.identifier.scopus2-s2.0-85160619816
dc.identifier.urihttp://hdl.handle.net/11449/248913
dc.language.isoeng
dc.relation.ispartofPharmaceuticals
dc.sourceScopus
dc.subjectbiopolymers
dc.subjectcranial nerve injuries
dc.subjectfacial expression
dc.subjectfacial muscles
dc.subjectfacial nerve
dc.subjectfacial nerve diseases
dc.subjectfibrin tissue adhesive
dc.subjectheterologous
dc.subjectlow-level light therapy
dc.subjecttransplantation
dc.titleMorphofunctional Improvement of the Facial Nerve and Muscles with Repair Using Heterologous Fibrin Biopolymer and Photobiomodulationen
dc.typeArtigo
unesp.author.orcid0000-0002-8963-8793[1]
unesp.author.orcid0000-0002-9914-1262[3]
unesp.author.orcid0000-0002-9855-5594[4]
unesp.author.orcid0000-0001-6952-0512[5]
unesp.author.orcid0000-0002-0674-3759[6]
unesp.author.orcid0000-0002-5881-2218[13]

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Botucatu - CEVAP - Centro de Estudos de Venenos e Animais Peçonhentos
Artigos - Doenças Tropicais e Diagnósticos por Imagem - FMB