FTY720 prevents renal T-Cell infiltration after ischemia/reperfusion injury

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dc.contributor.authorSuleiman, M.
dc.contributor.authorCury, P. M.
dc.contributor.authorPestana, JOM
dc.contributor.authorBurdmann, E. A.
dc.contributor.authorBueno, V
dc.contributor.institutionFaculdade de Medicina de São José do Rio Preto (FAMERP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2014-05-20T15:27:13Z
dc.date.available2014-05-20T15:27:13Z
dc.date.issued2005-01-01
dc.description.abstractIschemia/reperfusion (I/R) injury, a common early feature in renal transplantation, results from both free radical species generation and local inflammatory responses that attract different types of cells. The interaction with infiltrating leukocytes could promote damage and death of resident renal cells contributing to worsening of renal function. It has been shown that depletion of host T cells protects against kidney damage after I/R injury, although the mechanism is not fully understood. FTY720, a synthetic analog of a natural product extracted from Isaria sincclairii has shown modulatory properties in experimental models of autoimmune disease, transplantation, and I/R injury. FTY720 alters lymphocyte responses to chemokine homing signals, thereby decreasing the number of lymphocytes in inflammatory sites. We evaluated renal function in mice at 3, 5, and 7 days after I/R injury in the presence or absence of FTY720 treatment. FTY720 treatment promoted earlier recovery of renal function associated with a lower number of renal-infiltrating lymphocytes. These findings confirm previous results showing a protective effect of FTY720 in I/R injury models.en
dc.description.affiliationFAMERP, Sao Jose Rio Preto Med Sch, Dept Pathol, BR-15091280 São Paulo, Brazil
dc.description.affiliationFAMERP, Div Nephrol, BR-15091280 São Paulo, Brazil
dc.description.affiliationFAMERP, Immunol Lab, BR-15091280 São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, São Paulo, Brazil
dc.description.affiliationUniv Fed São Paulo, Renal Transplantat Grp, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, São Paulo, Brazil
dc.format.extent373-374
dc.identifierhttp://dx.doi.org/10.1016/j.transproceed.2004.12.280
dc.identifier.citationTransplantation Proceedings. New York: Elsevier B.V., v. 37, n. 1, p. 373-374, 2005.
dc.identifier.doi10.1016/j.transproceed.2004.12.280
dc.identifier.issn0041-1345
dc.identifier.urihttp://hdl.handle.net/11449/37246
dc.identifier.wosWOS:000228091300124
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofTransplantation Proceedings
dc.relation.ispartofjcr0.806
dc.relation.ispartofsjr0,422
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleFTY720 prevents renal T-Cell infiltration after ischemia/reperfusion injuryen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.orcid0000-0002-7644-8579[4]
unesp.author.orcid0000-0001-8954-129X[5]

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