Neurofibromin: a general outlook

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dc.contributor.authorTrovo-Marqui, A. B.
dc.contributor.authorTajara, E. H.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:25:53Z
dc.date.available2014-05-20T15:25:53Z
dc.date.issued2006-07-01
dc.description.abstractNeurofibromin is a cytoplasmic protein that is predominantly expressed in neurons, Schwann cells, oligodendrocytes, astrocytes and leukocytes. It is encoded by the gene NF1, located on chromosome 17, at q11.2, and has different biochemical functions, including association to microtubules and participation in several signaling pathways. Alterations in this protein are responsible for a phacomatosis named neurofibromatosis type 1.en
dc.description.affiliationFAMERP Fac Med Sao Jose do Rio Preto, Dept Biol Mol, BR-15090000 Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Biol, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Biol, São Paulo, Brazil
dc.format.extent1-13
dc.identifierhttp://dx.doi.org/10.1111/j.1399-0004.2006.00639.x
dc.identifier.citationClinical Genetics. Oxford: Blackwell Publishing, v. 70, n. 1, p. 1-13, 2006.
dc.identifier.doi10.1111/j.1399-0004.2006.00639.x
dc.identifier.issn0009-9163
dc.identifier.urihttp://hdl.handle.net/11449/36203
dc.identifier.wosWOS:000238485700001
dc.language.isoeng
dc.publisherBlackwell Publishing
dc.relation.ispartofClinical Genetics
dc.relation.ispartofjcr3.512
dc.relation.ispartofsjr1,522
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectcyclic AMPpt
dc.subjectmTOR proteinpt
dc.subjectneurofibromatosis type 1pt
dc.subjectneurofibrominpt
dc.subjectp21 raspt
dc.titleNeurofibromin: a general outlooken
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderBlackwell Publishing
unesp.author.orcid0000-0002-2603-2057[2]

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