Commissural NTS contributes to pressor responses to glutamate injected into the medial NTS of awake rats

dc.contributor.authorColombari, Eduardo [UNESP]
dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.contributor.authorTalman, W. T.
dc.contributor.institutionUNIV IOWA
dc.contributor.institutionVET AFFAIRS MED CTR
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:26:59Z
dc.date.available2014-05-20T15:26:59Z
dc.date.issued1996-06-01
dc.description.abstractIn the present study we investigated whether interruption of the chemoreceptor reflex by an electrolytic lesion of the commissural subnucleus of the nucleus tractus solitarii (commNTS) influenced presser and bradycardic responses induced by microinjection of L-glutamate (L-Glu) into the medial NTS (mNTS) of conscious rats. Seven days after sham lesions, seven rats demonstrated significant presser [change in mean arterial pressure (MAP) = +33 +/- 3 mmHg] and bradycardic [change in heart rate (HR) = -74 +/- 8 beats/min (bpm)] responses to chemoreceptor reflex activation by intravenous injection of KCN. Likewise, L-Glu (1 nmol in 100 nl) injected into the mNTS in sham rats induced presser (+29 +/- 2 mmHg) and bradycardic responses (-90 +/- 8 bpm). However, in 11 rats with lesions in commNTS, presser and bradycardic chemoreceptor reflex responses were abolished, and injection of L-Glu into the mNTS decreased MAP (-14 +/- 6 mmHg) and HR (-59 +/- 16 bpm) as is reported in anesthetized control rats. We conclude that presser responses induced by L-Glu microinjected into the baroreceptor reflex region of mNTS in conscious rats depend on the integrity of the commNTS, which plays an important role in central chemoreceptor reflex pathways.en
dc.description.affiliationUNIV IOWA, DEPT NEUROL, IOWA CITY, IA 52242 USA
dc.description.affiliationVET AFFAIRS MED CTR, IOWA CITY, IA 52242 USA
dc.description.affiliationPAULISTA STATE UNIV, SCH DENT, DEPT PHYSIOL, BR-14801903 ARARAQUARA, SP, BRAZIL
dc.description.affiliationUnespPAULISTA STATE UNIV, SCH DENT, DEPT PHYSIOL, BR-14801903 ARARAQUARA, SP, BRAZIL
dc.format.extentR1220-R1225
dc.identifierhttp://ajpregu.physiology.org/content/270/6/R1220
dc.identifier.citationAmerican Journal of Physiology-regulatory Integrative and Comparative Physiology. Bethesda: Amer Physiological Soc, v. 270, n. 6, p. R1220-R1225, 1996.
dc.identifier.issn0363-6119
dc.identifier.lattes4544450092427426
dc.identifier.lattes1023597870118105
dc.identifier.urihttp://hdl.handle.net/11449/37047
dc.identifier.wosWOS:A1996UU58900007
dc.language.isoeng
dc.publisherAmer Physiological Soc
dc.relation.ispartofAmerican Journal of Physiology: Regulatory Integrative and Comparative Physiology
dc.relation.ispartofjcr3.082
dc.relation.ispartofsjr1,550
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectarterial pressurept
dc.subjectbaroreceptorpt
dc.subjectchemoreceptorpt
dc.subjectexcitatory amino acidspt
dc.subjectKCNpt
dc.subjectmedullapt
dc.subjectnucleus tractus solitariipt
dc.titleCommissural NTS contributes to pressor responses to glutamate injected into the medial NTS of awake ratsen
dc.typeArtigo
dcterms.licensehttp://www.the-aps.org/mm/Publications/Info-For-Authors/Copyright
dcterms.rightsHolderAmer Physiological Soc
unesp.author.lattes4544450092427426[1]
unesp.author.lattes1023597870118105
unesp.author.orcid0000-0002-1395-4036[1]
unesp.author.orcid0000-0003-1167-4441[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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