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Regenerative endodontics

dc.contributor.authordos Reis-Prado, Alexandre Henrique
dc.contributor.authorde Castro Oliveira, Sabrina
dc.contributor.authorde Arantes, Lara Cancella
dc.contributor.authorGoto, Juliana [UNESP]
dc.contributor.authorBenetti, Francine
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T12:33:22Z
dc.date.available2023-07-29T12:33:22Z
dc.date.issued2022-08-31
dc.description.abstractPulp-dentin complex of immature permanent teeth can be damaged through microbial invasion caused by untreated tooth decay, trauma, and dental anomalies, consequently leading to pulp necrosis and incomplete root development without early intervention. Regenerative endodontic procedure (REP) has become a remarkable option of treatment for necrotic immature teeth compared to conventional root canal therapy. In addition to providing not only for a resolution of pain and periapical lesion, REP also allows an immunocompetent tissue formation into root canal space, resulting in continued root development through increased root length/thickness and apical closure. This approach relies on three principles of tissue engineering (signaling molecules release, stem cell proliferation, and a 3-dimensional scaffold), and requires a bacterial-free environment for more successful and more predictable long-term results. Histological studies with animals and humans have reported tissue repair rather than regeneration after REP. Clinical trials and long-term evaluations exploring new materials, protocols, and patient-centered outcomes are also necessary for REP in an effort to fill the gaps and provide stronger evidence in this field. This chapter will provide an overview of clinical indications and techniques in REP, in addition to discussing the new pathways of this therapy in endodontics.en
dc.description.affiliationDepartment of Restorative Dentistry Universidade Federal de Minas Gerais (UFMG) School of Dentistry
dc.description.affiliationDepartment of Restorative Dentistry São Paulo State University (UNESP) School of Dentistry
dc.description.affiliationUnespDepartment of Restorative Dentistry São Paulo State University (UNESP) School of Dentistry
dc.format.extent127-160
dc.identifier.citationConservative Treatment of Pulp Tissue: Indications, Materials and Techniques, p. 127-160.
dc.identifier.scopus2-s2.0-85140660584
dc.identifier.urihttp://hdl.handle.net/11449/246162
dc.language.isoeng
dc.relation.ispartofConservative Treatment of Pulp Tissue: Indications, Materials and Techniques
dc.sourceScopus
dc.subjectConservative treatment
dc.subjectGrowth factor(s)
dc.subjectGuided tissue regeneration
dc.subjectRegenerative endodontics
dc.subjectStem cells
dc.subjectTissue engineering
dc.titleRegenerative endodonticsen
dc.typeCapítulo de livro

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