Everyman's guide to bacterial insertion sequences

dc.contributor.authorSiguier, Patricia
dc.contributor.authorGourbeyre, Edith
dc.contributor.authorVarani, Alessandro [UNESP]
dc.contributor.authorTon-Hoang, Bao
dc.contributor.authorChandler, Mick
dc.contributor.institutionCNRS
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:01:13Z
dc.date.available2018-12-11T17:01:13Z
dc.date.issued2015-01-01
dc.description.abstractThe number and diversity of known prokaryotic insertion sequences (IS) have increased enormously since their discovery in the late 1960s. At present the sequences of more than 4000 different IS have been deposited in the specialized ISfinder database. Over time it has become increasingly apparent that they are important actors in the evolution of their host genomes and are involved in sequestering, transmitting, mutating and activating genes, and in the rearrangement of both plasmids and chromosomes. This review presents an overview of our current understanding of these transposable elements (TE), their organization and their transposition mechanism as well as their distribution and genomic impact. In spite of their diversity, they share only a very limited number of transposition mechanisms which we outline here. Prokaryotic IS are but one example of a variety of diverse TE which are being revealed due to the advent of extensive genome sequencing projects. A major conclusion from sequence comparisons of various TE is that frontiers between the different types are becoming less clear. We detail these receding frontiers between different IS-related TE. Several, more specialized chapters in this volume include additional detailed information concerning a number of these. In a second section of the review, we provide a detailed description of the expanding variety of IS, which we have divided into families for convenience. Our perception of these families continues to evolve and families emerge regularly as more IS are identified. This section is designed as an aid and a source of information for consultation by interested specialist readers.en
dc.description.affiliationLaboratoire de Microbiologie et Génétique Moléculaires CNRS
dc.description.affiliationDepartamento de Tecnologia Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal UNESP - Univ. Estadual Paulista
dc.description.affiliationUnespDepartamento de Tecnologia Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal UNESP - Univ. Estadual Paulista
dc.identifierhttp://dx.doi.org/10.1128/microbiolspec.MDNA3-0030-2014
dc.identifier.citationMicrobiology Spectrum, v. 3, n. 2, 2015.
dc.identifier.doi10.1128/microbiolspec.MDNA3-0030-2014
dc.identifier.file2-s2.0-84959056901.pdf
dc.identifier.issn2165-0497
dc.identifier.scopus2-s2.0-84959056901
dc.identifier.urihttp://hdl.handle.net/11449/172582
dc.language.isoeng
dc.relation.ispartofMicrobiology Spectrum
dc.relation.ispartofsjr1,814
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.titleEveryman's guide to bacterial insertion sequencesen
dc.typeArtigo

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