Influence of chronic alcoholism and oestrogen deficiency on the variation of stoichiometry of hydroxyapatite within alveolar bone crest of rats

dc.contributor.authorMarchini, Adriana M. P. S. [UNESP]
dc.contributor.authorDeco, Camila P. [UNESP]
dc.contributor.authorLodi, Karina B. [UNESP]
dc.contributor.authorMarchini, Leonardo [UNESP]
dc.contributor.authorSanto, Ana M. E.
dc.contributor.authorRocha, Rosilene F. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Vale Paraiba Univ
dc.contributor.institutionUniv Taubate UNITAU
dc.contributor.institutionUniv Vale Paraiba
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T14:04:35Z
dc.date.available2014-05-20T14:04:35Z
dc.date.issued2012-10-01
dc.description.abstractObjective: Previous findings suggest that chronic alcoholism and oestrogenic deficiency may affect bones in general (including alveolar bone) and increase individuals' susceptibility to the development of periodontal disease. The aim of this study was to assess possible alterations in the chemical composition of alveolar bone in rats subjected to chronic alcoholism, oestrogen deficiency or both.Design: Fifty-four rats were initially divided into two groups: ovariectomized (Ovx), and Sham operated (Sham). A month after surgery, the groups were sub-divided and received the following dietary intervention for eight weeks: 20% alcohol, isocaloric diet and ad libitum diet. Samples of the mandible, in the alveolar bone crest region, were analyzed to verify possible changes in the stoichiometric composition of bone hydroxyapatite, by measuring the relationship between the concentration of calcium and phosphorus (Ca/P ratios), using micro X-ray fluorescence spectrometry.Results: The ad libitum groups presented the highest average values of Ca/P ratios, while the groups with dietary restrictions presented the smallest average values. The Ovx ad libitum group presented the highest values of Ca/P ratios (2.03 +/- 0.04). However, these values were not considered statistically different (p > 0.05) from the Sham ad libitum group (2.01 +/- 0.01). The Ovx alcohol group presented lower values for Ca/P ratios (1.92 +/- 0.06), being the only group statistically different (p < 0.001) from the Sham ad libitum group. Potential confounding variables are discussed.Conclusion: Ovariectomy associated with alcohol consumption at 20% significantly changed the stoichiometry composition of hydroxyapatite in the alveolar bone crest, leading to a reduction in Ca/P ratios. (c) 2012 Elsevier Ltd. All rights reserved.en
dc.description.affiliationSão Paulo State Univ UNESP, Sao Jose Campos Sch Dent, Dept Biosci & Diagnost, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUniv Vale Paraiba Univ, Sch Dent, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUniv Taubate UNITAU, Dept Dent, Taubate, SP, Brazil
dc.description.affiliationUniv Vale Paraiba, Lab Biomed Vibrat Spect, Inst Res & Dev IP&D, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationFed Univ São Paulo UNIFESP, Dept Math & Earth Sci, Diadema, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Sao Jose Campos Sch Dent, Dept Biosci & Diagnost, Sao Jose Dos Campos, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent1385-1394
dc.identifierhttp://dx.doi.org/10.1016/j.archoralbio.2012.04.011
dc.identifier.citationArchives of Oral Biology. Oxford: Pergamon-Elsevier B.V. Ltd, v. 57, n. 10, p. 1385-1394, 2012.
dc.identifier.doi10.1016/j.archoralbio.2012.04.011
dc.identifier.issn0003-9969
dc.identifier.urihttp://hdl.handle.net/11449/22665
dc.identifier.wosWOS:000310409400011
dc.language.isoeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relation.ispartofArchives of Oral Biology
dc.relation.ispartofjcr2.050
dc.relation.ispartofsjr0,752
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAlcoholismen
dc.subjectOvariectomyen
dc.subjectPeriodontiumen
dc.subjectFluorescence spectrometryen
dc.subjectCalciumen
dc.subjectPhosphorousen
dc.titleInfluence of chronic alcoholism and oestrogen deficiency on the variation of stoichiometry of hydroxyapatite within alveolar bone crest of ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderPergamon-Elsevier B.V. Ltd
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campospt
unesp.departmentBiociências e Diagnóstico Bucal - ICTpt

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