Biocompatibility, bioactive potential, porosity, and interface analysis calcium silicate repair cements in a dentin tube model

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dc.contributor.authorInada, Rafaela Nanami Handa [UNESP]
dc.contributor.authorQueiroz, Marcela Borsatto [UNESP]
dc.contributor.authorLopes, Camila Soares [UNESP]
dc.contributor.authorSilva, Evelin Carine Alves [UNESP]
dc.contributor.authorTorres, Fernanda Ferrari Esteves [UNESP]
dc.contributor.authorda Silva, Guilherme Ferreira
dc.contributor.authorGuerreiro-Tanomaru, Juliane Maria [UNESP]
dc.contributor.authorCerri, Paulo Sérgio [UNESP]
dc.contributor.authorTanomaru-Filho, Mário [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionCentro Universitário Sagrado Coração (UNISAGRADO)
dc.date.accessioned2023-07-29T16:10:07Z
dc.date.available2023-07-29T16:10:07Z
dc.date.issued2023-01-01
dc.description.abstractObjectives: This study is to evaluate biocompatibility, bioactive potential, porosity, and dentin/material interface of Bio-C Repair (BIOC-R), MTA Repair HP (MTAHP), and Intermediate Restorative Material (IRM). Materials and methods: Dentin tubes were implanted into subcutaneous of rats for 7, 15, 30, and 60 days. Thickness of capsules, number of inflammatory cells (ICs), interleukin-6 (IL-6), osteocalcin (OCN), and von Kossa were evaluated. Porosity and material/dentin interface voids were also analyzed. Data were submitted to ANOVA and Tukey’s tests (p < 0.05). Results: IRM capsules were thicker and contained greater ICs and IL-6-immunopositive cells at 7 and 15 days. BIOC-R capsules exhibited higher thickness and ICs at 7 days and greater IL-6 at 7 and 15 days than MTAHP (p < 0.05). At 30 and 60 days, no significant difference was observed among the groups. OCN-immunopositive cells, von Kossa-positive, and birefringent structures were observed in BIOC-R and MTAHP. MTAHP exhibited higher porosity and interface voids (p < 0.05). Conclusions: BIOC-R, MTAHP, and IRM are biocompatible. Bioceramics materials demonstrate bioactive potential. MTAHP presented the highest porosity and presence of voids. Clinical relevance: BIOC-R and MTAHP have adequate biological properties. BIOC-R demonstrated lower porosity and presence of voids, which may represent better sealing for its clinical applications.en
dc.description.affiliationDepartment of Restorative Dentistry São Paulo State University (UNESP) School of Dentistry, Rua Humaitá, 1680, SP
dc.description.affiliationDepartment of Dentistry Centro Universitário Sagrado Coração (UNISAGRADO), Rua Irmã Armida, 10-50, SP
dc.description.affiliationDepartment of Morphology and Children Clinic São Paulo State University (UNESP) School of Dentistry, Rua Humaitá, 1680, SP
dc.description.affiliationUnespDepartment of Restorative Dentistry São Paulo State University (UNESP) School of Dentistry, Rua Humaitá, 1680, SP
dc.description.affiliationUnespDepartment of Morphology and Children Clinic São Paulo State University (UNESP) School of Dentistry, Rua Humaitá, 1680, SP
dc.identifierhttp://dx.doi.org/10.1007/s00784-023-05002-5
dc.identifier.citationClinical Oral Investigations.
dc.identifier.doi10.1007/s00784-023-05002-5
dc.identifier.issn1436-3771
dc.identifier.issn1432-6981
dc.identifier.scopus2-s2.0-85151568697
dc.identifier.urihttp://hdl.handle.net/11449/249820
dc.language.isoeng
dc.relation.ispartofClinical Oral Investigations
dc.sourceScopus
dc.subjectBiocompatibility
dc.subjectCalcium silicate
dc.subjectRoot repair materials
dc.subjectX-ray microtomography
dc.titleBiocompatibility, bioactive potential, porosity, and interface analysis calcium silicate repair cements in a dentin tube modelen
dc.typeArtigo

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