Electrical stimulation enhances tissue reorganization during orthodontic tooth movement in rats

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Spadari, Gisele Sampaio
Zaniboni, Ewerton
Vedovello, Silvia Amelia Scudeler
Santamaria, Mauro Pedrine [UNESP]
do Amaral, Maria Esméria Corezola
dos Santos, Gláucia Maria Tech
Esquisatto, Marcelo Augusto Marretto
Mendonca, Fernanda Aparecida Sampaio
Santamaria-Jr, Milton

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Objective: This study evaluated the effects of a low-intensity electric current on tissue reorganization during experimental orthodontic tooth movement. Materials and methods: Thirty-two animals were divided into two groups evaluated on days 3 and 7: OTM—orthodontic tooth movement and OTM + MC—orthodontic tooth movement and microcurrent application (10 μA/5 min). The samples were processed for histological, morphometric, and Western blotting analysis. Results: Analysis of the periodontal ligament (PL) showed a significantly smaller number of granulocytes in the OTM + MC group on day 7.The number of fibroblasts was significantly higher in the OTM + MC group on days 3 and 7. The area of birefringent collagen fibers was more organized in the OTM + MC group on days 3 and 7. The number of blood vessels was significantly higher in the OTM + MC group on day 7. Microcurrent application significantly increased the number of osteoclasts in the compression region of the PL. In the OTM + MC group on day 7 of tooth movement, the expression of TGF-β1 and VEGF was significantly reduced whereas the expression of bFGF was increased in PL. Conclusions: Electrical stimulation enhances tissue responses, reducing the number of granulocytes and increasing the number of fibroblasts, blood vessels, and osteoclasts and modulates the expression of TGF-β1, VEFG, and bFGF. Clinical relevance: This technique is used in many areas of medicine, but poorly explored in dentistry and orthodontics. This treatment is cheap and non-invasive and can be applied by own orthodontist, and it can improve the treatment with a faster and safe tooth movement, without pain.



Low-intensity electric current, Microcurrent application, Orthodontic tooth movement

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Clinical Oral Investigations, v. 21, n. 1, p. 111-120, 2017.