Electrical stimulation enhances tissue reorganization during orthodontic tooth movement in rats

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dc.contributor.authorSpadari, Gisele Sampaio
dc.contributor.authorZaniboni, Ewerton
dc.contributor.authorVedovello, Silvia Amelia Scudeler
dc.contributor.authorSantamaria, Mauro Pedrine [UNESP]
dc.contributor.authordo Amaral, Maria Esméria Corezola
dc.contributor.authordos Santos, Gláucia Maria Tech
dc.contributor.authorEsquisatto, Marcelo Augusto Marretto
dc.contributor.authorMendonca, Fernanda Aparecida Sampaio
dc.contributor.authorSantamaria-Jr, Milton
dc.contributor.institutionUNIARARAS
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:28:43Z
dc.date.available2018-12-11T17:28:43Z
dc.date.issued2017-01-01
dc.description.abstractObjective: This study evaluated the effects of a low-intensity electric current on tissue reorganization during experimental orthodontic tooth movement. Materials and methods: Thirty-two animals were divided into two groups evaluated on days 3 and 7: OTM—orthodontic tooth movement and OTM + MC—orthodontic tooth movement and microcurrent application (10 μA/5 min). The samples were processed for histological, morphometric, and Western blotting analysis. Results: Analysis of the periodontal ligament (PL) showed a significantly smaller number of granulocytes in the OTM + MC group on day 7.The number of fibroblasts was significantly higher in the OTM + MC group on days 3 and 7. The area of birefringent collagen fibers was more organized in the OTM + MC group on days 3 and 7. The number of blood vessels was significantly higher in the OTM + MC group on day 7. Microcurrent application significantly increased the number of osteoclasts in the compression region of the PL. In the OTM + MC group on day 7 of tooth movement, the expression of TGF-β1 and VEGF was significantly reduced whereas the expression of bFGF was increased in PL. Conclusions: Electrical stimulation enhances tissue responses, reducing the number of granulocytes and increasing the number of fibroblasts, blood vessels, and osteoclasts and modulates the expression of TGF-β1, VEFG, and bFGF. Clinical relevance: This technique is used in many areas of medicine, but poorly explored in dentistry and orthodontics. This treatment is cheap and non-invasive and can be applied by own orthodontist, and it can improve the treatment with a faster and safe tooth movement, without pain.en
dc.description.affiliationGraduate Program of Orthodontics Heminio Ometto University Center UNIARARAS, Dr. Maximiliano Baruto, 500
dc.description.affiliationSchool of Dentistry Heminio Ometto University Center UNIARARAS, Dr. Maximiliano Baruto, 500
dc.description.affiliationGraduate Program of Biomedical Sciences Heminio Ometto University Center UNIARARAS, Dr. Maximiliano Baruto, 500
dc.description.affiliationDivision of Periodontics College of Dentistry State University of São Paulo UNESP, Av. Eng. Francisco José Longo, 777
dc.description.affiliationUnespDivision of Periodontics College of Dentistry State University of São Paulo UNESP, Av. Eng. Francisco José Longo, 777
dc.format.extent111-120
dc.identifierhttp://dx.doi.org/10.1007/s00784-016-1759-6
dc.identifier.citationClinical Oral Investigations, v. 21, n. 1, p. 111-120, 2017.
dc.identifier.doi10.1007/s00784-016-1759-6
dc.identifier.file2-s2.0-84975744045.pdf
dc.identifier.issn1436-3771
dc.identifier.issn1432-6981
dc.identifier.lattes7008114923397947
dc.identifier.scopus2-s2.0-84975744045
dc.identifier.urihttp://hdl.handle.net/11449/178093
dc.language.isoeng
dc.relation.ispartofClinical Oral Investigations
dc.relation.ispartofsjr0,986
dc.relation.ispartofsjr0,986
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectLow-intensity electric current
dc.subjectMicrocurrent application
dc.subjectOrthodontic tooth movement
dc.titleElectrical stimulation enhances tissue reorganization during orthodontic tooth movement in ratsen
dc.typeArtigo
unesp.author.lattes7008114923397947

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Artigos - Diagnóstico e Cirurgia - ICT