Electrical stimulation enhances tissue reorganization during orthodontic tooth movement in rats
dc.contributor.author | Spadari, Gisele Sampaio | |
dc.contributor.author | Zaniboni, Ewerton | |
dc.contributor.author | Vedovello, Silvia Amelia Scudeler | |
dc.contributor.author | Santamaria, Mauro Pedrine [UNESP] | |
dc.contributor.author | do Amaral, Maria Esméria Corezola | |
dc.contributor.author | dos Santos, Gláucia Maria Tech | |
dc.contributor.author | Esquisatto, Marcelo Augusto Marretto | |
dc.contributor.author | Mendonca, Fernanda Aparecida Sampaio | |
dc.contributor.author | Santamaria-Jr, Milton | |
dc.contributor.institution | UNIARARAS | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2018-12-11T17:28:43Z | |
dc.date.available | 2018-12-11T17:28:43Z | |
dc.date.issued | 2017-01-01 | |
dc.description.abstract | Objective: This study evaluated the effects of a low-intensity electric current on tissue reorganization during experimental orthodontic tooth movement. Materials and methods: Thirty-two animals were divided into two groups evaluated on days 3 and 7: OTM—orthodontic tooth movement and OTM + MC—orthodontic tooth movement and microcurrent application (10 μA/5 min). The samples were processed for histological, morphometric, and Western blotting analysis. Results: Analysis of the periodontal ligament (PL) showed a significantly smaller number of granulocytes in the OTM + MC group on day 7.The number of fibroblasts was significantly higher in the OTM + MC group on days 3 and 7. The area of birefringent collagen fibers was more organized in the OTM + MC group on days 3 and 7. The number of blood vessels was significantly higher in the OTM + MC group on day 7. Microcurrent application significantly increased the number of osteoclasts in the compression region of the PL. In the OTM + MC group on day 7 of tooth movement, the expression of TGF-β1 and VEGF was significantly reduced whereas the expression of bFGF was increased in PL. Conclusions: Electrical stimulation enhances tissue responses, reducing the number of granulocytes and increasing the number of fibroblasts, blood vessels, and osteoclasts and modulates the expression of TGF-β1, VEFG, and bFGF. Clinical relevance: This technique is used in many areas of medicine, but poorly explored in dentistry and orthodontics. This treatment is cheap and non-invasive and can be applied by own orthodontist, and it can improve the treatment with a faster and safe tooth movement, without pain. | en |
dc.description.affiliation | Graduate Program of Orthodontics Heminio Ometto University Center UNIARARAS, Dr. Maximiliano Baruto, 500 | |
dc.description.affiliation | School of Dentistry Heminio Ometto University Center UNIARARAS, Dr. Maximiliano Baruto, 500 | |
dc.description.affiliation | Graduate Program of Biomedical Sciences Heminio Ometto University Center UNIARARAS, Dr. Maximiliano Baruto, 500 | |
dc.description.affiliation | Division of Periodontics College of Dentistry State University of São Paulo UNESP, Av. Eng. Francisco José Longo, 777 | |
dc.description.affiliationUnesp | Division of Periodontics College of Dentistry State University of São Paulo UNESP, Av. Eng. Francisco José Longo, 777 | |
dc.format.extent | 111-120 | |
dc.identifier | http://dx.doi.org/10.1007/s00784-016-1759-6 | |
dc.identifier.citation | Clinical Oral Investigations, v. 21, n. 1, p. 111-120, 2017. | |
dc.identifier.doi | 10.1007/s00784-016-1759-6 | |
dc.identifier.file | 2-s2.0-84975744045.pdf | |
dc.identifier.issn | 1436-3771 | |
dc.identifier.issn | 1432-6981 | |
dc.identifier.lattes | 7008114923397947 | |
dc.identifier.scopus | 2-s2.0-84975744045 | |
dc.identifier.uri | http://hdl.handle.net/11449/178093 | |
dc.language.iso | eng | |
dc.relation.ispartof | Clinical Oral Investigations | |
dc.relation.ispartofsjr | 0,986 | |
dc.relation.ispartofsjr | 0,986 | |
dc.rights.accessRights | Acesso aberto | |
dc.source | Scopus | |
dc.subject | Low-intensity electric current | |
dc.subject | Microcurrent application | |
dc.subject | Orthodontic tooth movement | |
dc.title | Electrical stimulation enhances tissue reorganization during orthodontic tooth movement in rats | en |
dc.type | Artigo | |
unesp.author.lattes | 7008114923397947 |
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