Publicação: Features of 847 Childhood-Onset Systemic Lupus Erythematosus Patients in Three Age Groups at Diagnosis: A Brazilian Multicenter Study
dc.contributor.author | Gomes, Roberta C. | |
dc.contributor.author | Silva, Marco F. | |
dc.contributor.author | Kozu, Katia | |
dc.contributor.author | Bonfá, Eloisa | |
dc.contributor.author | Pereira, Rosa M. | |
dc.contributor.author | Terreri, Maria T. | |
dc.contributor.author | Magalhães, Claudia S. [UNESP] | |
dc.contributor.author | Sacchetti, Silvana B. | |
dc.contributor.author | Marini, Roberto | |
dc.contributor.author | Fraga, Melissa | |
dc.contributor.author | Carvalho, Luciana M. | |
dc.contributor.author | Barbosa, Cássia M. | |
dc.contributor.author | Carneiro-Sampaio, Magda | |
dc.contributor.author | Silva, Clovis A. | |
dc.contributor.institution | Universidade de São Paulo (USP) | |
dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Irmandade da Santa Casa de Misericórdia de Sao Paulo | |
dc.contributor.institution | Universidade Estadual de Campinas (UNICAMP) | |
dc.contributor.institution | Hospital Infantil Darcy Vargas | |
dc.date.accessioned | 2018-12-11T16:43:37Z | |
dc.date.available | 2018-12-11T16:43:37Z | |
dc.date.issued | 2016-11-01 | |
dc.description.abstract | Objective: To evaluate demographic data and clinical and laboratory features at disease diagnosis in 3 different age groups of childhood-onset systemic lupus erythematosus (SLE): group A, early-onset (<6 years); group B, school age (≥6 to <12 years); and group C, adolescent (≥12 to <18 years). Methods: This was a Brazilian multicenter cohort retrospective study in 10 pediatric rheumatology centers, including 847 childhood-onset SLE patients. Results: Patients were divided into 3 groups: group A with 39 patients (4%), group B with 395 patients (47%), and group C with 413 patients (49%). Of 39 childhood-onset SLE patients in group A, 3 (8%) were ages <2 years, 4 (10%) were ≥2 to <3 years, and 32 (82%) were ≥3 and <6 years. A total of 74 childhood-onset SLE patients were analyzed for C1q levels, and complete C1q deficiency was observed in 3 of 74 patients (4%), all in group A. Groups were similar regarding high frequencies of female sex, nephritis, neuropsychiatric involvement, Systemic Lupus Erythematosus Disease Activity Index 2000 score ≥8, autoantibody profile, elevated acute phase proteins, and low complement levels (P > 0.05). However, the frequency of fever (78% versus 61% versus 47%; P < 0.0001), hepatomegaly (42% versus 29% versus 14%; P < 0.0001), splenomegaly (28% versus 12% versus 4%; P < 0.0001), and discoid lupus (13% versus 4% versus 4%; P = 0.020) was significantly higher in group A compared to groups B and C. The frequency of weight loss >2 kg (19% versus 28% versus 36%; P = 0.017), photosensitivity (34% versus 41% versus 51%; P = 0.006), leukopenia <4,000/mm3 (14% versus 25% versus 30%; P = 0.048), and lymphopenia <1,500/mm3 (22% versus 41% versus 47%; P = 0.011) was significantly lower in group A. Conclusion: Our large multicenter study identified the finding that the initial appearance of childhood-onset SLE is characterized by comparable high frequency of internal organ involvement and some distinct clinical and laboratory features in early-onset and adolescent groups. | en |
dc.description.affiliation | Faculdade de Medicina da Universidade de Sao Paulo | |
dc.description.affiliation | Universidade Federal de Sao Paulo | |
dc.description.affiliation | Sao Paulo State University (UNESP) | |
dc.description.affiliation | Irmandade da Santa Casa de Misericórdia de Sao Paulo | |
dc.description.affiliation | State University of Campinas (UNICAMP) | |
dc.description.affiliation | University of Sao Paulo | |
dc.description.affiliation | Hospital Infantil Darcy Vargas | |
dc.description.affiliationUnesp | Sao Paulo State University (UNESP) | |
dc.format.extent | 1736-1741 | |
dc.identifier | http://dx.doi.org/10.1002/acr.22881 | |
dc.identifier.citation | Arthritis Care and Research, v. 68, n. 11, p. 1736-1741, 2016. | |
dc.identifier.doi | 10.1002/acr.22881 | |
dc.identifier.issn | 2151-4658 | |
dc.identifier.issn | 2151-464X | |
dc.identifier.scopus | 2-s2.0-84983499302 | |
dc.identifier.uri | http://hdl.handle.net/11449/168917 | |
dc.language.iso | eng | |
dc.relation.ispartof | Arthritis Care and Research | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Scopus | |
dc.title | Features of 847 Childhood-Onset Systemic Lupus Erythematosus Patients in Three Age Groups at Diagnosis: A Brazilian Multicenter Study | en |
dc.type | Artigo | |
dspace.entity.type | Publication |