Paracoccidioides brasiliensis isolated from armadillos is virulent to Syrian hamsters

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dc.contributor.authorPeracoli, MTS
dc.contributor.authorSugizaki, M. F.
dc.contributor.authorMendes, R. P.
dc.contributor.authorNaiff, R.
dc.contributor.authorMontenegro, M. R.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInst Nacl Pesquisas Amazonia
dc.date.accessioned2014-05-20T13:50:32Z
dc.date.available2014-05-20T13:50:32Z
dc.date.issued1999-01-01
dc.description.abstractIsolates of Paracoccidioides brasiliensis may vary in virulence according to time of in vitro subcultivation. The present study compared the morphology and pathogenicity to hamsters of two P. brasiliensis isolates: one obtained from human lesions and maintained in the laboratory for several years (Pb-18) and the other isolate recovered from hamsters inoculated with organ homogenates from armadillos (Pb-T). The microscopic morphology of Pb-18 and Pb-T showed yeast cells with similar diameter. However, Pb-T produced a significantly higher number of buds per mother cell than Pb-18. Besides, the mycelial form of Pb-T developed abundant sporulation during 8 weeks of culture which was absent in the Pb-18 isolate. Virulence studies demonstrated that mortality rates, antibody levels, fungal load and extent of lesions in the organs were significantly higher in animals infected with Pb-T. The results demonstrated that Pb-T recently isolated from an animal was more virulent than Pb-18. These differences between the two P. brasillensis isolates may be indicators of virulence attenuation in this fungal species.en
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias, Dept Microbiol & Imunol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Med, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationInst Nacl Pesquisas Amazonia, Manaus, Amazonas, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biociencias, Dept Microbiol & Imunol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Med, BR-18618000 Botucatu, SP, Brazil
dc.format.extent123-130
dc.identifierhttp://dx.doi.org/10.1023/A:1007119403572
dc.identifier.citationMycopathologia. Dordrecht: Kluwer Academic Publ, v. 148, n. 3, p. 123-130, 1999.
dc.identifier.doi10.1023/A:1007119403572
dc.identifier.issn0301-486X
dc.identifier.urihttp://hdl.handle.net/11449/18034
dc.identifier.wosWOS:000165381200004
dc.language.isoeng
dc.publisherKluwer Academic Publ
dc.relation.ispartofMycopathologia
dc.relation.ispartofjcr1.476
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectantibodiespt
dc.subjectarmadillopt
dc.subjectexperimental infectionpt
dc.subjecthamsterpt
dc.subjectParacoccidioides brasiliensispt
dc.subjectvirulencept
dc.titleParacoccidioides brasiliensis isolated from armadillos is virulent to Syrian hamstersen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights
dcterms.rightsHolderKluwer Academic Publ
unesp.author.orcid0000-0002-0936-9512[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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