Human leukocyte antigen (HLA)-F and -G gene polymorphisms and haplotypes are associated with malaria susceptibility in the Beninese Toffin children

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dc.contributor.authorSonon, Paulin
dc.contributor.authorTokplonou, Léonidas
dc.contributor.authorSadissou, Ibrahim
dc.contributor.authorM'po, Kuumaaté K.G.
dc.contributor.authorGlitho, Sonya S.C.
dc.contributor.authorAgniwo, Privat
dc.contributor.authorIbikounlé, Moudachirou
dc.contributor.authorSouza, Andréia S. [UNESP]
dc.contributor.authorMassaro, Juliana Doblas
dc.contributor.authorGonzalez, Daniel
dc.contributor.authorTchégninougbo, Théophile
dc.contributor.authorAyitchédji, Aurèle
dc.contributor.authorMassougbodji, Achille
dc.contributor.authorMoreau, Philippe
dc.contributor.authorGarcia, André
dc.contributor.authorMilet, Jacqueline
dc.contributor.authorSabbagh, Audrey
dc.contributor.authorMendes-Junior, Celso T.
dc.contributor.authorMoutairou, Kabirou A.
dc.contributor.authorCastelli, Erick C. [UNESP]
dc.contributor.authorCourtin, David
dc.contributor.authorDonadi, Eduardo A.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de Pernambuco (UFPE)
dc.contributor.institutionCotonou
dc.contributor.institutionUniversité de Paris
dc.contributor.institutionUniversité d'Abomey-Calavi
dc.contributor.institutionUniversity of Montpellier
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionSô Ava
dc.contributor.institutionService de Recherches en Hémato-Immunologie
dc.contributor.institutionInstitut de Recherche Saint-Louis
dc.date.accessioned2021-06-25T11:03:24Z
dc.date.available2021-06-25T11:03:24Z
dc.date.issued2021-08-01
dc.description.abstractBackground: Little attention has been devoted to the role of the immunoregulatory HLA-E/-F/−G genes in malaria. We evaluated the entire HLA-E/-F/−G variability in Beninese children highly exposed to Plasmodium falciparum (P.f.) malaria. Methods: 154 unrelated children were followed-up for six months and evaluated for the presence and number of malaria episodes. HLA-E/-F/−G genes were genotyped using massively parallel sequencing. Anti P.f. antibodies were evaluated using ELISA. Results: Children carrying the G allele at HLA-F (−1499,rs183540921) showed increased P.f. asymptomatic/symptomatic ratio, suggesting that these children experienced more asymptomatic P.f. episodes than symptomatic one. Children carrying HLA-G-UTR-03 haplotype exhibited increased risk for symptomatic P.f. episodes and showed lower IgG2 response against P.f. GLURP-R2 when compared to the non-carriers. No associations were observed for the HLA-E gene. Conclusion: HLA-F associations may be related to the differential expression profiles of the encoded immunomodulatory molecules, and the regulatory sites at the HLA-G 3'UTR may be associated to posttranscriptional regulation of HLA-G and to host humoral response against P.f.en
dc.description.affiliationPost-graduate Program in Basic and Applied Immunology Ribeirão Preto Medical School University of São Paulo, Avenida Bandeirantes, 3900, Monte Alegre
dc.description.affiliationImmunogenetic Laboratory Immunology Department Aggeu Magalhães Institute, Oswaldo Cruz Foundation, Av. Moraes rego, s/n, Campus da UFPE, Cidade Universitária
dc.description.affiliationCentre d'Etude et de Recherche sur le Paludisme Associé à la Grossesse et à l'Enfance (CERPAGE) faculté des Sciences de la Santé Cotonou
dc.description.affiliationUniversité de Paris, UMR 261 MERIT, IRD
dc.description.affiliationDépartement de Zoologie faculté des Sciences et Techniques Université d'Abomey-Calavi
dc.description.affiliationIntertryp IRD Cirad University of Montpellier, Avenue Agropolis
dc.description.affiliationSão Paulo State University (UNESP) School of Medicine Molecular Genetics and Bioinformatics Laboratory, Av. Prof. Dr. Walter Maurício Correa, s/n
dc.description.affiliationCentre Médical Saint Joseph Sô Ava
dc.description.affiliationCEA DRF-Institut François Jacob Service de Recherches en Hémato-Immunologie, Hopital Saint-Louis
dc.description.affiliationUniversité de Paris CEA U976 HIPI Unit (Human Immunology Physiopathology Immunotherapy) Institut de Recherche Saint-Louis
dc.description.affiliationDepartamento de Química Faculdade de Filosofia Ciências e Letras de Ribeirão Preto Universidade de São Paulo, AV Bandeirantes, 3900
dc.description.affiliationLaboratoire de Biologie et Physiologie Cellulaire Université d'Abomey-Calavi
dc.description.affiliationSão Paulo State University (UNESP) Department of Pathology School of Medicine
dc.description.affiliationUnespSão Paulo State University (UNESP) School of Medicine Molecular Genetics and Bioinformatics Laboratory, Av. Prof. Dr. Walter Maurício Correa, s/n
dc.description.affiliationUnespSão Paulo State University (UNESP) Department of Pathology School of Medicine
dc.description.sponsorshipInstitut de Recherche pour le Développement
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCAPES: #304931/2014-1
dc.description.sponsorshipIdCAPES: #466036/2013-5
dc.description.sponsorshipIdCAPES: 302060/2019-07
dc.description.sponsorshipIdCAPES: 406594/2013-9
dc.description.sponsorshipIdCNPq: PROCAD#88881-068436/2014-1
dc.identifierhttp://dx.doi.org/10.1016/j.meegid.2021.104828
dc.identifier.citationInfection, Genetics and Evolution, v. 92.
dc.identifier.doi10.1016/j.meegid.2021.104828
dc.identifier.issn1567-7257
dc.identifier.issn1567-1348
dc.identifier.scopus2-s2.0-85103729480
dc.identifier.urihttp://hdl.handle.net/11449/207927
dc.language.isoeng
dc.relation.ispartofInfection, Genetics and Evolution
dc.sourceScopus
dc.subjectAntibody
dc.subjectHaplotype
dc.subjectHLA-Ib
dc.subjectPlasmodium falciparum
dc.subjectSNV
dc.titleHuman leukocyte antigen (HLA)-F and -G gene polymorphisms and haplotypes are associated with malaria susceptibility in the Beninese Toffin childrenen
dc.typeArtigo

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Artigos - Microbiologia e Imunologia - IBB