Cervicovaginal Levels of Proinflammatory Cytokines Are Increased During Chlamydial Infection in Bacterial Vaginosis But Not in Lactobacilli-Dominated Flora

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dc.contributor.authorMarconi, Camila [UNESP]
dc.contributor.authorSantos-Greatti, Mariana M. V. [UNESP]
dc.contributor.authorParada, Cristina Maria Garcia de Lima [UNESP]
dc.contributor.authorPontes, Anaglória [UNESP]
dc.contributor.authorPontes, Anaglória [UNESP]
dc.contributor.authorGiraldo, Paulo C.
dc.contributor.authorDonders, Gilbert G. G.
dc.contributor.authorSilva, Marcia Guimarães da [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniv Hosp Gasthuisberg
dc.date.accessioned2014-12-03T13:10:36Z
dc.date.available2014-12-03T13:10:36Z
dc.date.issued2014-07-01
dc.description.abstractObjective. The purpose of this study was to assess the cervicovaginal levels of proinflammatory cytokines in women with Chlamydia trachomatis (CT) infection in the presence of bacterial vaginosis (BV) and normal flora and to compare with those negative for CT.Materials and Methods. In this cross-sectional study, nonpregnant women were enrolled at 2 outpatient clinics and at 1 primary medical care unit in Sao Paulo State, Brazil. Cervicovaginal samples from 256 women with BV, of which 68 (26.6%) had concomitant CT infection and 188 (73.4%) were CT-negative, were measured for interleukin-1 beta (IL-1 beta), IL-6, and IL-8 by enzyme-linked immunosorbent assay. A matching number of samples from women with normal flora, CT-positive (n = 68) and negative (n = 188), were evaluated as control. Cytokine levels were compared by Mann-Whitney test and differences were considered significant at p < .05.Results. In CT-negative women, IL-1 beta was increased in BV (p < .001) when compared to normal flora, while the levels of IL-6 and IL8 were unchanged. The presence of CT infection was not associated with differences on cytokine levels in women with normal flora. However, women with BV had higher levels of IL-1 beta (p = .02), IL-6 (p = .02), and IL-8 (p = .03) in the presence of CT when compared to those who tested negative for CT.Conclusions. Detection of endocervical CT is associated with increased cervicovaginal IL-1 beta, IL-6, and IL-8 levels in women with concomitant BV but not in those with normal flora.en
dc.description.affiliationUNESP Univ Estadual Paulista, Botucatu Med Sch, Dept Pathol, Campinas, SP, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Botucatu Med Sch, Dept Nursing, Campinas, SP, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Botucatu Med Sch, Dept Gynecol & Obstet, Campinas, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Fac Ciencias Med, Dept Gynecol & Obstet, Campinas, SP, Brazil
dc.description.affiliationUniv Hosp Gasthuisberg, Leuven, Belgium
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Botucatu Med Sch, Dept Pathol, Campinas, SP, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Botucatu Med Sch, Dept Nursing, Campinas, SP, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Botucatu Med Sch, Dept Gynecol & Obstet, Campinas, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 08/55420-6
dc.description.sponsorshipIdFAPESP: 09/50560-7
dc.description.sponsorshipIdCAPES: 1179-09-8
dc.format.extent261-265
dc.identifierhttp://dx.doi.org/10.1097/LGT.0000000000000003
dc.identifier.citationJournal of Lower Genital Tract Disease. Philadelphia: Lippincott Williams & Wilkins, v. 18, n. 3, p. 261-265, 2014.
dc.identifier.issn1089-2591
dc.identifier.lattes0514178654667684
dc.identifier.lattes0514178654667684
dc.identifier.lattes4940791909535775
dc.identifier.urihttp://hdl.handle.net/11449/112310
dc.identifier.wosWOS:000338030900012
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofJournal of Lower Genital Tract Disease
dc.relation.ispartofjcr1.494
dc.relation.ispartofsjr0,602
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectbacterial vaginosisen
dc.subjectChlamydia trachomatisen
dc.subjectendocervicitisen
dc.subjectcytokineen
dc.titleCervicovaginal Levels of Proinflammatory Cytokines Are Increased During Chlamydial Infection in Bacterial Vaginosis But Not in Lactobacilli-Dominated Floraen
dc.typeArtigo
dcterms.rightsHolderLippincott Williams & Wilkins
unesp.author.lattes0514178654667684
unesp.author.lattes0514178654667684
unesp.author.lattes4940791909535775
unesp.author.orcid0000-0001-7742-1186[1]
unesp.author.orcid0000-0002-9597-3635[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Patologia - FMB
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Artigos - Ginecologia e Obstetrícia - FMB