Cell-mediated and humoral immunity in West syndrome

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Montelli, T. C. B.
Iwasso, M. T. R.
Peracoli, M. T. S.
Mota, N. G. S.

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The immunological status of five children with West syndrome consequent to previous cerebral lesions was investigated. Three children had West syndrome and two were in transition from West to Lennox-Gastaut syndrome. All of them showed cellular immunological deficiencies in the following tests: sensitization to DNCB, intracutaneous reaction to PHA, inhibition of leukocyte migration, blastic transformation of lymphocytes, T and B lymphocytes in peripheral blood and levels of serum immunoglobulins. These immunological deficiencies, of different degrees of severity, were associated with frequent infections in these children. A possible association between the immunological deficiencies and autoimmunity is discussed.



1 chloro 2,4 dinitrobenzene, clonazepam, corticotropin, nitrazepam, phenobarbital, phytohemagglutinin, b lymphocyte, brain injury, cellular immunity, central nervous system, drug therapy, electroencephalography, etiology, humoral immunity, immune deficiency, infant, lennox gastaut syndrome, major clinical study, pathogenesis, preschool child, t lymphocyte, therapy, west syndrome, Antibody Formation, Case Report, Child, Preschool, Female, Human, Immunity, Cellular, Immunoglobulins, Infant, Lymphocyte Activation, Male, Skin Tests, Spasms, Infantile, Syndrome

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Arquivos de Neuro-Psiquiatria, v. 39, n. 1, p. 1-12, 1981.