Histopathological biomarkers in pacu (Piaractus mesopotamicus) infected with aeromonas hydrophila and treated with antibiotics
dc.contributor.author | Carraschi, Silvia Patricia [UNESP] | |
dc.contributor.author | da Cruz, Claudinei [UNESP] | |
dc.contributor.author | Machado Neto, Joaquim Goncalves [UNESP] | |
dc.contributor.author | Ignacio, Naiara Fernanda [UNESP] | |
dc.contributor.author | Barbuio, Roberto [UNESP] | |
dc.contributor.author | Fernandes Machado, Marcia Rita [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2014-05-20T13:14:48Z | |
dc.date.available | 2014-05-20T13:14:48Z | |
dc.date.issued | 2012-09-01 | |
dc.description.abstract | Pharmacochemicals usage in fish farming disease treatment can cause morphological and functional changes in absorption capacity, metabolism and excretion organs. The aim of this research was to evaluate the histopathological biomarkers in the gills, liver, kidney and skin of pacu (P mesopotamicus), which have been infected with A. hydrophila and treated with oxytetracycline (OTC) and florfenicol (FFC). Fish were exposed to 2.4 x 10(7) mL(-1) of A. hydrophila bacteria experimental infection and after 24 h exposed to FFC treatment for ten days and OTC for seven days. OTC was not effective in the A. hydrophila control in pacu in Up to 170.0 mg kg(-1) concentration. Nevertheless, FFC was 100% effective with 10.0 mg kg(-1) concentration. After the treatment, skin, gills, liver and kidney samples were collected and processed for histopathological analysis. A. hydrophila caused lamellar fusion, sub epithelial edema, mucous hypertrophy and hyperplasia, lining, pillar and chloride cells. Hepatocytes hypertrophy was observed on liver, as a result of the antibiotics metabolism and bacteria cell wall. The histopathological biomarkers show the effects of the presence of the A. hydrophila. The use of the antibiotic florfenicol decreases the bacterial action effectiveness on tissues evaluated. Thus, the histopathological biomarkers show the A. hydrophila effect and the antibiotics treatment. The skin and liver are exposure biomarkers for both. (c) 2012 Elsevier B.V. All rights reserved. | en |
dc.description.affiliation | Univ Estadual Paulista, Aquaculture Ctr, São Paulo, Brazil | |
dc.description.affiliation | Univ Estadual Paulista, Coll Agr & Vet Sci, São Paulo, Brazil | |
dc.description.affiliation | Unesp Jaboticabal, Coll Agr & Vet Sci, Pesticides Ecotoxicol & Occupat Hlth Lab, São Paulo, Brazil | |
dc.description.affiliation | Unesp Jaboticabal, Coll Agr & Vet Sci, Dept Morphol & Anim Physiol, São Paulo, Brazil | |
dc.description.affiliationUnesp | Univ Estadual Paulista, Aquaculture Ctr, São Paulo, Brazil | |
dc.description.affiliationUnesp | Univ Estadual Paulista, Coll Agr & Vet Sci, São Paulo, Brazil | |
dc.description.affiliationUnesp | Unesp Jaboticabal, Coll Agr & Vet Sci, Pesticides Ecotoxicol & Occupat Hlth Lab, São Paulo, Brazil | |
dc.description.affiliationUnesp | Unesp Jaboticabal, Coll Agr & Vet Sci, Dept Morphol & Anim Physiol, São Paulo, Brazil | |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description.sponsorshipId | FAPESP: 08-51900-3 | |
dc.format.extent | 115-120 | |
dc.identifier | http://dx.doi.org/10.1016/j.ecoenv.2012.06.016 | |
dc.identifier.citation | Ecotoxicology and Environmental Safety. San Diego: Academic Press Inc. Elsevier B.V., v. 83, p. 115-120, 2012. | |
dc.identifier.doi | 10.1016/j.ecoenv.2012.06.016 | |
dc.identifier.issn | 0147-6513 | |
dc.identifier.lattes | 1902601000093854 | |
dc.identifier.uri | http://hdl.handle.net/11449/2147 | |
dc.identifier.wos | WOS:000307129700016 | |
dc.language.iso | eng | |
dc.publisher | Academic Press Inc. Elsevier B.V. | |
dc.relation.ispartof | Ecotoxicology and Environmental Safety | |
dc.relation.ispartofjcr | 3.974 | |
dc.relation.ispartofsjr | 1,201 | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | Fish | en |
dc.subject | Disease | en |
dc.subject | Histological Biomarkers | en |
dc.subject | Bacteria | en |
dc.title | Histopathological biomarkers in pacu (Piaractus mesopotamicus) infected with aeromonas hydrophila and treated with antibiotics | en |
dc.type | Artigo | |
dcterms.license | http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy | |
dcterms.rightsHolder | Academic Press Inc. Elsevier B.V. | |
unesp.author.lattes | 1902601000093854 | |
unesp.campus | Universidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal | pt |
unesp.department | Morfologia e Fisiologia Animal - FCAV | pt |
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