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Histopathological biomarkers in pacu (Piaractus mesopotamicus) infected with aeromonas hydrophila and treated with antibiotics

dc.contributor.authorCarraschi, Silvia Patricia [UNESP]
dc.contributor.authorda Cruz, Claudinei [UNESP]
dc.contributor.authorMachado Neto, Joaquim Goncalves [UNESP]
dc.contributor.authorIgnacio, Naiara Fernanda [UNESP]
dc.contributor.authorBarbuio, Roberto [UNESP]
dc.contributor.authorFernandes Machado, Marcia Rita [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:14:48Z
dc.date.available2014-05-20T13:14:48Z
dc.date.issued2012-09-01
dc.description.abstractPharmacochemicals usage in fish farming disease treatment can cause morphological and functional changes in absorption capacity, metabolism and excretion organs. The aim of this research was to evaluate the histopathological biomarkers in the gills, liver, kidney and skin of pacu (P mesopotamicus), which have been infected with A. hydrophila and treated with oxytetracycline (OTC) and florfenicol (FFC). Fish were exposed to 2.4 x 10(7) mL(-1) of A. hydrophila bacteria experimental infection and after 24 h exposed to FFC treatment for ten days and OTC for seven days. OTC was not effective in the A. hydrophila control in pacu in Up to 170.0 mg kg(-1) concentration. Nevertheless, FFC was 100% effective with 10.0 mg kg(-1) concentration. After the treatment, skin, gills, liver and kidney samples were collected and processed for histopathological analysis. A. hydrophila caused lamellar fusion, sub epithelial edema, mucous hypertrophy and hyperplasia, lining, pillar and chloride cells. Hepatocytes hypertrophy was observed on liver, as a result of the antibiotics metabolism and bacteria cell wall. The histopathological biomarkers show the effects of the presence of the A. hydrophila. The use of the antibiotic florfenicol decreases the bacterial action effectiveness on tissues evaluated. Thus, the histopathological biomarkers show the A. hydrophila effect and the antibiotics treatment. The skin and liver are exposure biomarkers for both. (c) 2012 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, Aquaculture Ctr, São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Coll Agr & Vet Sci, São Paulo, Brazil
dc.description.affiliationUnesp Jaboticabal, Coll Agr & Vet Sci, Pesticides Ecotoxicol & Occupat Hlth Lab, São Paulo, Brazil
dc.description.affiliationUnesp Jaboticabal, Coll Agr & Vet Sci, Dept Morphol & Anim Physiol, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Aquaculture Ctr, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Coll Agr & Vet Sci, São Paulo, Brazil
dc.description.affiliationUnespUnesp Jaboticabal, Coll Agr & Vet Sci, Pesticides Ecotoxicol & Occupat Hlth Lab, São Paulo, Brazil
dc.description.affiliationUnespUnesp Jaboticabal, Coll Agr & Vet Sci, Dept Morphol & Anim Physiol, São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 08-51900-3
dc.format.extent115-120
dc.identifierhttp://dx.doi.org/10.1016/j.ecoenv.2012.06.016
dc.identifier.citationEcotoxicology and Environmental Safety. San Diego: Academic Press Inc. Elsevier B.V., v. 83, p. 115-120, 2012.
dc.identifier.doi10.1016/j.ecoenv.2012.06.016
dc.identifier.issn0147-6513
dc.identifier.lattes1902601000093854
dc.identifier.urihttp://hdl.handle.net/11449/2147
dc.identifier.wosWOS:000307129700016
dc.language.isoeng
dc.publisherAcademic Press Inc. Elsevier B.V.
dc.relation.ispartofEcotoxicology and Environmental Safety
dc.relation.ispartofjcr3.974
dc.relation.ispartofsjr1,201
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectFishen
dc.subjectDiseaseen
dc.subjectHistological Biomarkersen
dc.subjectBacteriaen
dc.titleHistopathological biomarkers in pacu (Piaractus mesopotamicus) infected with aeromonas hydrophila and treated with antibioticsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderAcademic Press Inc. Elsevier B.V.
unesp.author.lattes1902601000093854
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt
unesp.departmentMorfologia e Fisiologia Animal - FCAVpt

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