Agaricus blazei (Himematsutake) does not alter the development of rat diethylnitrosamine-initiated hepatic preneoplastic foci

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dc.contributor.authorBarbisan, L. F.
dc.contributor.authorSpinardi-Barbisan, ALT
dc.contributor.authorMoreira, ELT
dc.contributor.authorSalvadori, Daisy Maria Favero [UNESP]
dc.contributor.authorRibeiro, L. R.
dc.contributor.authorda Eira, A. F.
dc.contributor.authorde Camargo, JLV
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal da Bahia (UFBA)
dc.contributor.institutionUniv Luterana Brasil
dc.date.accessioned2014-05-20T13:36:54Z
dc.date.available2014-05-20T13:36:54Z
dc.date.issued2003-02-01
dc.description.abstractThe modifying potential of crude extracts of the mushroom Agaricus blazei Murrill (Himematsutake) on the development and growth of glutathione S-transferase placental form (GST-P)-positive liver foci (liver preneoplastic lesion) was investigated in adult male Wistar rats. Six groups of animals were used. Groups 2 to 5 were given a single i.p. injection of 200 mg/kg b.w. of diethylnitrosamine (DEN) and groups 1 and 6 were treated with saline at the beginning of the experiment. After 2 weeks, animals of groups 3 to 6 were orally treated with three dose levels of aqueous extracts of the mushroom A. blazei (1.2, 5.6, 11.5, and 11.5 mg/ml of dry weight of solids) for 6 weeks. All animals were subjected to two-thirds partial hepatectomy at week 3 and sacrificed at week 8. Two hours before sacrifice, ten animals of each group were administered a single i.p injection of 100 mg/kg of bromodeoxyuridine (BrdU). Apoptotic bodies and BrdU-positive hepatocyte nuclei were quantified in liver sections stained for hematoxylin and eosin (H&E) (eosinophilic foci) and simultaneously stained for GST-P expression (GST-P-positive foci), respectively. The 6-week treatment with A. blazei did not alter the development (number and size) of GST-P-positive foci and did not affect the growth kinetics of liver normal parenchyma or foci in DEN-initiated animals. Our results indicate that the treatment with aqueous extracts of the mushroom A. blazei during the post-initiation stage of rat liver carcinogenesis does not exert any protective effect against the development of GST-P-positive foci induced by DEN. (Cancer Sci 2003; 94: 188-192).en
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, TOXICAN, Fac Med, Dept Patol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, TOXICAN, Fac Med, Dept Morfol,Inst Biol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUFBA, Escola Med Vet, Dept Patol & Clin, BR-70170111 Salvador, BA, Brazil
dc.description.affiliationUniv Luterana Brasil, ULBRA, BR-92001970 Canoas, RS, Brazil
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Fac Ciências Agronom, Dept Prod Vegetal Modulo Cogumelos, BR-18603970 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, TOXICAN, Fac Med, Dept Patol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, TOXICAN, Fac Med, Dept Morfol,Inst Biol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Fac Ciências Agronom, Dept Prod Vegetal Modulo Cogumelos, BR-18603970 Botucatu, SP, Brazil
dc.format.extent188-192
dc.identifierhttp://dx.doi.org/10.1111/j.1349-7006.2003.tb01417.x
dc.identifier.citationCancer Science. Tokyo: Japanese Cancer Assoc, v. 94, n. 2, p. 188-192, 2003.
dc.identifier.doi10.1111/j.1349-7006.2003.tb01417.x
dc.identifier.fileWOS000182370200009.pdf
dc.identifier.issn1347-9032
dc.identifier.lattes3278528112652257
dc.identifier.lattes5051118752980903
dc.identifier.urihttp://hdl.handle.net/11449/12700
dc.identifier.wosWOS:000182370200009
dc.language.isoeng
dc.publisherJapanese Cancer Assoc
dc.relation.ispartofCancer Science
dc.relation.ispartofsjr1,744
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleAgaricus blazei (Himematsutake) does not alter the development of rat diethylnitrosamine-initiated hepatic preneoplastic focien
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderJapanese Cancer Assoc
unesp.author.lattes3278528112652257
unesp.author.lattes5051118752980903
unesp.author.orcid0000-0001-9323-3134[4]
unesp.author.orcid0000-0003-3833-4172[7]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agronômicas, Botucatupt
unesp.departmentProdução Vegetalpt
unesp.departmentProdução e Melhoramento Vegetal - FCApt

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Botucatu - FCA - Faculdade de Ciências Agronômicas