Antineoplasic Drug Methotrexate Redox Mechanism Using a Glassy Carbon Electrode

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dc.contributor.authorPontinha, A. D. R.
dc.contributor.authorJorge, S. M. A. [UNESP]
dc.contributor.authorDiculescu, V. C.
dc.contributor.authorVivan, M.
dc.contributor.authorOliveira-Brett, A. M.
dc.contributor.institutionUniv Coimbra
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionHosp Univ Coimbra
dc.date.accessioned2014-05-20T13:53:32Z
dc.date.available2014-05-20T13:53:32Z
dc.date.issued2012-04-01
dc.description.abstractMethotrexate (MTX) is an antimetabolite of folic acid indicated in the treatment of a variety of cancers. The electrochemical behaviour of MTX on a glassy carbon electrode was investigated. The MTX oxidation is a complex, pH-dependent, diffusion-controlled irreversible process and proceeds with the transfer of two electrons and two protons and the formation of one electroactive product, 7-hydroxymethotrexate that undergoes a reversible redox reaction. The MTX reduction is a pH-dependent, quasi-reversible process and involves the transfer of two electrons and two protons leading to the formation of an electroactive product.en
dc.description.affiliationUniv Coimbra, Dept Quim, Fac Ciencias & Tecnol, P-3004535 Coimbra, Portugal
dc.description.affiliationUNESP, Dept Quim & Bioquim, Inst Biociencias, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationHosp Univ Coimbra, P-3000 Coimbra, Portugal
dc.description.affiliationUnespUNESP, Dept Quim & Bioquim, Inst Biociencias, BR-18618000 Botucatu, SP, Brazil
dc.description.sponsorshipFundação para a Ciência e a Tecnologia (FCT)
dc.description.sponsorshipEuropean Community Fund FEDER
dc.description.sponsorshipCEMUC-R
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFCT: SFRH/BD/46026/2008
dc.description.sponsorshipIdFCT: SFRH/BPD/36110/2007
dc.description.sponsorshipIdFCT: PTDC/QUI/098562/2008
dc.description.sponsorshipIdFCT: PTDC/SAU-BEB/104643/2008
dc.description.sponsorshipIdEuropean Community Fund FEDER: POCI 2010
dc.description.sponsorshipIdCEMUC-R: 285
dc.description.sponsorshipIdCAPES: 1211-08-0
dc.format.extent917-923
dc.identifierhttp://dx.doi.org/10.1002/elan.201100558
dc.identifier.citationElectroanalysis. Weinheim: Wiley-v C H Verlag Gmbh, v. 24, n. 4, p. 917-923, 2012.
dc.identifier.doi10.1002/elan.201100558
dc.identifier.issn1040-0397
dc.identifier.lattes5216150705972509
dc.identifier.urihttp://hdl.handle.net/11449/19103
dc.identifier.wosWOS:000302160000026
dc.language.isoeng
dc.publisherWiley-v C H Verlag Gmbh
dc.relation.ispartofElectroanalysis
dc.relation.ispartofjcr2.851
dc.relation.ispartofsjr0,692
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectGlassy carbonen
dc.subjectMethotrexateen
dc.subjectOxidationen
dc.subjectReductionen
dc.titleAntineoplasic Drug Methotrexate Redox Mechanism Using a Glassy Carbon Electrodeen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-v C H Verlag Gmbh
unesp.author.lattes5216150705972509
unesp.author.orcid0000-0002-6244-0891[5]
unesp.author.orcid0000-0003-0719-8016[3]
unesp.author.orcid0000-0002-0400-4645[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.departmentQuímica e Bioquímica - IBBpt

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