Potential tuberculostatic agent: Micelle-forming pyrazinamide prodrug

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dc.contributor.authorSilva, M.
dc.contributor.authorRicelli, N. L.
dc.contributor.authorEl Seoud, O.
dc.contributor.authorValentim, C. S.
dc.contributor.authorFerreira, A. G.
dc.contributor.authorSato, D. N.
dc.contributor.authorLeitel, CQF
dc.contributor.authorFerreira, E. I.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionInstituto Adolfo Lutz (IAL)
dc.date.accessioned2014-05-20T13:24:28Z
dc.date.available2014-05-20T13:24:28Z
dc.date.issued2006-06-01
dc.description.abstractPyrazinamide was condensed with the poly(ethylene glycol)-poly(aspartic acid) copolymer (PEG-PASP), a micelle-forming derivative was obtained that was characterized in terms of its critical micelle concentration (CMC) and micelle diameter. The CMC was found by observing the solubility of Sudan III in Poly(ethylene glycol)-poly(pyrazinamidomethyl aspartate) copolymer (PEG-PASP-PZA) solutions. The mean diameter of PEG-PASP-PZA micelles, obtained by analyzing the dynamic light-scattering data, was 78.2 nm. The PEG-PASP-PZA derivative, when assayed for anti-Mycobacterium activity, exhibited stronger activity than the simple drug.en
dc.description.affiliationUniv Estadual Paulista, Fac Ciências Farmaceut, BR-14801210 Araraquara, SP, Brazil
dc.description.affiliationUniv São Paulo, Fac Ciências Farmaceut, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Inst Quim, São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Quim, Araraquara, SP, Brazil
dc.description.affiliationUniv Fed Sao Carlos, Ctr Ciências Exatas & Tecnol, São Paulo, Brazil
dc.description.affiliationInst Adolfo Lutz Registro, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciências Farmaceut, BR-14801210 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim, Araraquara, SP, Brazil
dc.format.extent283-290
dc.identifierhttp://dx.doi.org/10.1002/ardp.200500039
dc.identifier.citationArchiv Der Pharmazie. Weinheim: Wiley-v C H Verlag Gmbh, v. 339, n. 6, p. 283-290, 2006.
dc.identifier.doi10.1002/ardp.200500039
dc.identifier.issn0365-6233
dc.identifier.urihttp://hdl.handle.net/11449/7598
dc.identifier.wosWOS:000238395100001
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofArchiv Der Pharmazie
dc.relation.ispartofjcr2.288
dc.relation.ispartofsjr0,413
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectpyrazinamidept
dc.subjectmicelle-forming polymerpt
dc.subjecttuberculostatic prodrugpt
dc.titlePotential tuberculostatic agent: Micelle-forming pyrazinamide prodrugen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell

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