Assessment of the potential genotoxic risk of medicinal Tamarindus indica fruit pulp extract using in vivo assays

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dc.contributor.authorSilva, F. M. V.
dc.contributor.authorLeite, M. F.
dc.contributor.authorSpadaro, A. C. C.
dc.contributor.authorUyemura, S. A.
dc.contributor.authorMaistro, Edson Luis [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Jose do Rosario Vellano
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T13:31:44Z
dc.date.available2014-05-20T13:31:44Z
dc.date.issued2009-01-01
dc.description.abstractTamarindus indica has been used in folk medicine as an antidiabetic, a digestive aid, and a carminative, among other uses. Currently, there is no information in the toxicology literature concerning the safety of T. indica extract. We evaluated the clastogenic and/or genotoxic potential of fruit pulp extract of this plant in vivo in peripheral blood and liver cells of Wistar rats, using the comet assay, and in bone marrow cells of Swiss mice, using the micronucleus test. The extract was administered by gavage at doses of 1000, 1500 and 2000 mg/kg body weight. Peripheral blood and liver cells from Wistar rats were collected 24 h after treatment, for the comet assay. The micronucleus test was carried out in bone marrow cells from Swiss mice collected 24 h after treatment. The extract made with T. indica was devoid of clastogenic and genotoxic activities in the cells of the rodents, when administered orally at these three acute doses.en
dc.description.affiliationUniv Estadual Paulista, Dept Fonoaudiol, Fac Filosofia & Ciencias, Marilia, SP, Brazil
dc.description.affiliationUniv Jose do Rosario Vellano, Genet Lab, Alfenas, MG, Brazil
dc.description.affiliationUniv São Paulo, Dept Quim & Fis, Fac Ciencias Farmaceut, BR-14049 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv São Paulo, Dept Anal Clin Toxicol & Bromatol, Fac Ciencias Farmaceut, BR-14049 Ribeirao Preto, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Fonoaudiol, Fac Filosofia & Ciencias, Marilia, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 06/57514-2
dc.description.sponsorshipIdFAPEMIG: 1879/02
dc.description.sponsorshipIdCNPq: 306544/2006-7
dc.format.extent1085-1092
dc.identifierhttp://dx.doi.org/10.4238/vol8-3gmr630
dc.identifier.citationGenetics and Molecular Research. Ribeirao Preto: Funpec-editora, v. 8, n. 3, p. 1085-1092, 2009.
dc.identifier.doi10.4238/vol8-3gmr630
dc.identifier.fileWOS000272050000016.pdf
dc.identifier.issn1676-5680
dc.identifier.lattes4787521613038315
dc.identifier.orcid0000-0003-0757-7876
dc.identifier.urihttp://hdl.handle.net/11449/10812
dc.identifier.wosWOS:000272050000016
dc.language.isoeng
dc.publisherFunpec-editora
dc.relation.ispartofGenetics and Molecular Research
dc.relation.ispartofsjr0,439
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectTamarindus indicaen
dc.subjectMicronucleus testen
dc.subjectComet assayen
dc.subjectMedicinal planten
dc.subjectSingle-cell gel electrophoresisen
dc.titleAssessment of the potential genotoxic risk of medicinal Tamarindus indica fruit pulp extract using in vivo assaysen
dc.typeArtigo
dcterms.licensehttp://www.geneticsmr.com/node/2
dcterms.rightsHolderFunpec-editora
unesp.author.lattes4787521613038315[5]
unesp.author.orcid0000-0003-0757-7876[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Filosofia e Ciências, Maríliapt

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Artigos - Fonoaudiologia - FFC