Silver-Coated Silica Nanoparticles Modified with MPS: Potential Antimicrobial Biomaterials Applied in Glaze and Soft Reliner

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dc.contributor.authorRossi, Natália Rivoli [UNESP]
dc.contributor.authorde Menezes, Beatriz Rossi Canuto
dc.contributor.authorSampaio, Aline da Graça [UNESP]
dc.contributor.authorda Silva, Diego Morais [UNESP]
dc.contributor.authorKoga-Ito, Cristiane Yumi [UNESP]
dc.contributor.authorThim, Gilmar Patrocínio
dc.contributor.authorPaes-Junior, Tarcisio José de Arruda [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionAeronautical Technology Institute (ITA)
dc.date.accessioned2023-07-29T15:12:46Z
dc.date.available2023-07-29T15:12:46Z
dc.date.issued2022-10-01
dc.description.abstractSoft reliner and glaze are materials used over full or partial dental prosthesis to prevent excessive pressure on the supporting tissues. They are also indicated as supportive treatment for dental stomatitis, especially when modified by the addition of medications. The objective of the work was to evaluate the antimicrobial effect of silver-coated silica nanoparticles in a glaze and a soft reliner. The nanoparticles were synthesized, characterized, and tested by minimum inhibitory concentration (MIC) for C. albicans SC5314. Then, the nanoparticles were incorporated to a glaze and a soft reliner, which were called nanocomposites. Then, the nanocomposites were divided into six groups (n = 12): CG: glaze/reliner; CR: reliner; G1: glaze + 1% nanoparticles/reliner; G2: glaze + 2.5% nanoparticles/reliner; R1: reliner + 1%; R2: reliner + 2.5%. The nanocomposites were characterized by a goniometer and by a scanning electron microscope. The antibiofilm test was performed against C. albicans SC5314. According to the MIC results, the non-functionalized nanoparticles reduced fungal growth at 1000 μg/mL and the functionalized nanoparticles at 2000 μg/mL. The functionalized nanoparticle had a superior dispersion being selected for the antibiofilm test. There was a reduction of 64% in CFU/specimen count for the glaze, not statistically significant (p = 0.244). For the soft reliner, there was an increase in CFU/specimen with the presence of nanoparticles, still not statistically significant (p = 0.264). In conclusion, it is necessary to conduct new studies to increase the release of silver, thus improving nanoparticles’ antifungal potential.en
dc.description.affiliationDepartment of Dental Materials and Prosthodontics Institute of Science and Technology São Paulo State University (UNESP)
dc.description.affiliationPlasma and Process Laboratory Aeronautical Technology Institute (ITA)
dc.description.affiliationDepartment of Environmental Engineering and Sciences Applied to Oral Health Graduate Program Institute of Science and Technology São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Dental Materials and Prosthodontics Institute of Science and Technology São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Environmental Engineering and Sciences Applied to Oral Health Graduate Program Institute of Science and Technology São Paulo State University (UNESP)
dc.identifierhttp://dx.doi.org/10.3390/polym14204306
dc.identifier.citationPolymers, v. 14, n. 20, 2022.
dc.identifier.doi10.3390/polym14204306
dc.identifier.issn2073-4360
dc.identifier.scopus2-s2.0-85140874470
dc.identifier.urihttp://hdl.handle.net/11449/249317
dc.language.isoeng
dc.relation.ispartofPolymers
dc.sourceScopus
dc.subjectbiofilms
dc.subjectdenture liners
dc.subjectnanoparticles
dc.subjectpolymers
dc.subjectsilver
dc.titleSilver-Coated Silica Nanoparticles Modified with MPS: Potential Antimicrobial Biomaterials Applied in Glaze and Soft Relineren
dc.typeArtigo
unesp.author.orcid0000-0001-9605-3921[2]
unesp.author.orcid0000-0001-9453-3905[3]
unesp.author.orcid0000-0003-0271-9142[4]
unesp.author.orcid0000-0002-2416-2173[5]
unesp.author.orcid0000-0001-8446-0474[7]

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