Epigenetic reprogramming in periodontal disease: Dynamic crosstalk with potential impact in oncogenesis

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dc.contributor.authorBarros, Silvana P.
dc.contributor.authorFahimipour, Farahnaz
dc.contributor.authorTarran, Robert
dc.contributor.authorKim, Steven
dc.contributor.authorScarel-Caminaga, Raquel Mantuaneli [UNESP]
dc.contributor.authorJustice, Anne
dc.contributor.authorNorth, Kari
dc.contributor.institutionUniversity of North Carolina at Chapel Hill
dc.contributor.institutionThe University of North Carolina at Chapel Hill
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionGeisinger Health Weis Center for Research
dc.date.accessioned2020-12-12T01:50:18Z
dc.date.available2020-12-12T01:50:18Z
dc.date.issued2020-02-01
dc.description.abstractPeriodontitis is a chronic multifactorial inflammatory disease associated with microbial dysbiosis and characterized by progressive destruction of the periodontal tissues. Such chronic infectious inflammatory disease is recognized as a major public health problem worldwide with measurable impact in systemic health. It has become evident that the periodontal disease phenotypes are not only determined by the microbiome effect, but the extent of the tissue response is also driven by the host genome and epigenome patterns responding to various environmental exposures. More recently there is mounting evidence indicating that epigenetic reprogramming in response to combined intrinsic and environmental exposures, might be particularly relevant due its plasticity and potential application towards precision health. The complex epigenetic crosstalk is reflected in the prognosis and progress of periodontal diseases and may also lead to a favorable landscape for cancer development. This review discusses epigenomics modifications focusing on the role of DNA methylation and pathways linking microbial infection and inflammatory pathways, which are also associated with carcinogenesis. There is a more clear vision whereas 'omics' technologies applied to unveil relevant epigenetic factors could play a significant role in the treatment of periodontal disease in a personalized mode, evidencing that public health approach should coexist with precision individualized treatment.en
dc.description.affiliationDepartment of Periodontology University of North Carolina at Chapel Hill
dc.description.affiliationDepartment of Cell Biology & Physiology Marsico Lung Institute The University of North Carolina at Chapel Hill
dc.description.affiliationDepartment of Morphology School of Dentistry at Araraquara UNESP- São Paulo State University
dc.description.affiliationBiomedical and Translational Informatics Geisinger Health Weis Center for Research
dc.description.affiliationDepartment of Epidemiology Gillings School of Global Public Health University of North Carolina at Chapel Hill
dc.description.affiliationUnespDepartment of Morphology School of Dentistry at Araraquara UNESP- São Paulo State University
dc.format.extent157-172
dc.identifierhttp://dx.doi.org/10.1111/prd.12322
dc.identifier.citationPeriodontology 2000, v. 82, n. 1, p. 157-172, 2020.
dc.identifier.doi10.1111/prd.12322
dc.identifier.issn1600-0757
dc.identifier.issn0906-6713
dc.identifier.scopus2-s2.0-85076619662
dc.identifier.urihttp://hdl.handle.net/11449/199824
dc.language.isoeng
dc.relation.ispartofPeriodontology 2000
dc.sourceScopus
dc.subjectepigenetic
dc.subjectinflammation
dc.subjectoncogenesis
dc.subjectperiodontal disease
dc.titleEpigenetic reprogramming in periodontal disease: Dynamic crosstalk with potential impact in oncogenesisen
dc.typeResenha

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