Effects of extracts from Brazilian sun-mushroom (Agaricus blazei) on the NK activity and lymphoproliferative responsiveness of Ehrlich tumor-bearing mice

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dc.contributor.authorKaneno, Ramon [UNESP]
dc.contributor.authorFontanari, L. M.
dc.contributor.authorSantos, S. A.
dc.contributor.authorDi Stasi, L. C.
dc.contributor.authorRodrigues, E.
dc.contributor.authorEira, A. F.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.date.accessioned2014-05-20T13:49:02Z
dc.date.available2014-05-20T13:49:02Z
dc.date.issued2004-06-01
dc.description.abstractAgaricus blazei Murrill, is an edible and medicinal mushroom which is popularly consumed due to its antitumoral properties. The immunomodulatory effects of methanol (METH), dichloromethane (DM) and n-hexane (HEX) extracts of this mushroom were evaluated in Ehrlich tumor-bearing mice. Subcutaneous inoculation of Ehrlich tumor cells inhibited the natural killer (NK) activity of spleen cells (specific lysis = 6.18 +/- 2.56%) compared with normal mice (17.59 +/- 7.77%). Treatment of tumor-bearing mice with the extracts for 10 days restored the natural killer activity against Yac-1 target cells and the best results were observed by treatment with the HEX extract (21.48 +/- 15.26%). Treatment of the animals with the HEX extract for 10 days was also able to stimulate the mitogen-induced lymphoproliferative activity of spleen cells. Thirty days after the treatment, all groups presented low proliferative activity. Specific antibody production was observed to be higher in the groups treated with the DM or METH extract 30 days after the treatment. Analysis of the 3 extracts by gas chromatography mass spectrum (GCMS) and magnetic nuclear resonance (MNR) showed that the HEX extract contains mainly sugar and fatty acids and that the METH extract also contains sugar and possibly amino acids. (C) 2004 Elsevier Ltd. All rights reserved.en
dc.description.affiliationSão Paulo State Univ, UNESP, Dept Microbiol & Immunol, Inst Biosci, Botucatu, SP, Brazil
dc.description.affiliationUSP, FMRP, Dept Biochem & Immunol, Ribeirao Preto, Brazil
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, IBB, Dept Pharmacol, Botucatu, SP, Brazil
dc.description.affiliationUFSCAR, Dept Chem, Sao Carlos, SP, Brazil
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, FCA, Dept Vegetable Prod, Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Dept Microbiol & Immunol, Inst Biosci, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, IBB, Dept Pharmacol, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, FCA, Dept Vegetable Prod, Botucatu, SP, Brazil
dc.format.extent909-916
dc.identifierhttp://dx.doi.org/10.1016/j.fct.2004.01.014
dc.identifier.citationFood and Chemical Toxicology. Oxford: Pergamon-Elsevier B.V., v. 42, n. 6, p. 909-916, 2004.
dc.identifier.doi10.1016/j.fct.2004.01.014
dc.identifier.issn0278-6915
dc.identifier.lattes8845835550637809
dc.identifier.lattes1697547325096457
dc.identifier.orcid0000-0002-4292-3298
dc.identifier.urihttp://hdl.handle.net/11449/17464
dc.identifier.wosWOS:000221448800005
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofFood and Chemical Toxicology
dc.relation.ispartofjcr3.977
dc.relation.ispartofsjr1,144
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAgaricus blazeipt
dc.subjectEhrlichpt
dc.subjectmushroompt
dc.subjectnatural killerpt
dc.subjecttumorpt
dc.titleEffects of extracts from Brazilian sun-mushroom (Agaricus blazei) on the NK activity and lymphoproliferative responsiveness of Ehrlich tumor-bearing miceen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes1697547325096457
unesp.author.lattes8845835550637809[1]
unesp.author.orcid0000-0003-4305-0326[5]
unesp.author.orcid0000-0002-7864-1073[4]
unesp.author.orcid0000-0002-4292-3298[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agronômicas, Botucatupt

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