Evaluation of Clinical and Inflammatory Markers of Nonalcoholic Fatty Liver Disease in Postmenopausal Women with Metabolic Syndrome

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dc.contributor.authorRodrigues, Marcio Hipolito [UNESP]
dc.contributor.authorBruno, Anderson Souza [UNESP]
dc.contributor.authorNahas-Neto, Jorge [UNESP]
dc.contributor.authorSandrim, Valeria C.
dc.contributor.authorMuniz, Ludmila G.
dc.contributor.authorNahás, Eliana Aguiar Petri [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Fed Ouro Preto
dc.contributor.institutionInst Res & Teaching Santa Casa de Misericordia Be
dc.date.accessioned2015-03-18T15:54:42Z
dc.date.available2015-03-18T15:54:42Z
dc.date.issued2014-08-01
dc.description.abstractBackground: The aim of this study was to assess clinical and inflammatory markers in nonalcoholic fatty liver disease (NAFLD) in postmenopausal women with metabolic syndrome.Methods: This cross-sectional study included 180 Brazilian women (age >= 45 years and amenorrhea >= 12 months). Metabolic syndrome was diagnosed by the presence of at least three of the following indicators: Waist circumference (WC) > 88 cm, triglycerides (TGs) >= 150 mg/dL, high-density lipoprotein (HDL) < 50 mg/dL; blood pressure >= 130/85 mmHg; and glucose >= 100 mg/dL. NAFLD was diagnosed by abdominal ultrasound. Participants were divided into three groups: Metabolic syndrome alone (n = 53); metabolic syndrome + NAFLD (n = 67); or absence of metabolic syndrome or NAFLD (control, n = 60). Clinical, anthropometric, and biochemical variables were quantified. The inflammatory profile included adiponectin, interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha). Data were submitted to statistical analysis using a Tukey test, analysis of variance (ANOVA), chi-squared, Pearson correlation, and logistic regression (odds ratio, OR).Results: Women with metabolic syndrome + NAFLD, abdominal obesity, high glucose, and insulin resistance by HOMA-IR were compared to women with metabolic syndrome alone and controls (P < 0.05). High values of IL-6 and TNF-alpha and low values of adiponectin were observed among women with metabolic syndrome alone or metabolic syndrome + NAFLD when compared to controls (P < 0.05). In multivariate analysis, the variables considered as risk of NAFLD development were: High systolic blood pressure (SBP) [(OR 1.02, 95% confidence interval (CI) 1.0-1.04]; large WC (OR 1.07, 95% CI 1.01-1.13); insulin resistance (OR 3.81, 95% CI 2.01-7.13); and metabolic syndrome (OR 8.68, 95% CI 3.3-24.1). Adiponectin levels reduced NAFLD risk (OR 0.88, 95% CI 0.80-0.96).Conclusion: In postmenopausal women, metabolic syndrome, abdominal obesity, and insulin resistance were risk markers for the development of NAFLD, whereas higher adiponectin values indicated a protection marker.en
dc.description.affiliationSao Paulo State Univ UNESP, Botucatu Med Sch, Dept Gynecol & Obstet, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Ouro Preto, Dept Gynecol & Obstet, Ouro Preto, MG, Brazil
dc.description.affiliationInst Res & Teaching Santa Casa de Misericordia Be, Belo Horizonte, MG, Brazil
dc.description.affiliationUnespSao Paulo State Univ UNESP, Botucatu Med Sch, Dept Gynecol & Obstet, Sao Paulo, Brazil
dc.format.extent330-338
dc.identifierhttp://dx.doi.org/10.1089/met.2013.0140
dc.identifier.citationMetabolic Syndrome And Related Disorders. New Rochelle: Mary Ann Liebert, Inc, v. 12, n. 6, p. 330-338, 2014.
dc.identifier.doi10.1089/met.2013.0140
dc.identifier.issn1540-4196
dc.identifier.lattes4155170574788417
dc.identifier.urihttp://hdl.handle.net/11449/116993
dc.identifier.wosWOS:000340196500005
dc.language.isoeng
dc.publisherMary Ann Liebert, Inc
dc.relation.ispartofMetabolic Syndrome And Related Disorders
dc.relation.ispartofjcr1.744
dc.relation.ispartofsjr0,837
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleEvaluation of Clinical and Inflammatory Markers of Nonalcoholic Fatty Liver Disease in Postmenopausal Women with Metabolic Syndromeen
dc.typeArtigo
dcterms.rightsHolderMary Ann Liebert, Inc
unesp.author.lattes4155170574788417
unesp.author.orcid0000-0002-6168-7470[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Ginecologia e Obstetrícia - FMB