Design, characterization, and biological evaluation of curcumin-loaded surfactant-based systems for topical drug delivery

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dc.contributor.authorFonseca-Santos, Bruno [UNESP]
dc.contributor.authorSantos, Aline Martins dos [UNESP]
dc.contributor.authorRodero, Camila Fernanda [UNESP]
dc.contributor.authorDaflon Gremiao, Maria Palmira [UNESP]
dc.contributor.authorChorilli, Marlus [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-11-27T21:07:53Z
dc.date.available2018-11-27T21:07:53Z
dc.date.issued2016-01-01
dc.description.abstractFrom previous studies, it has been found that curcumin exhibits an anti-inflammatory activity and is being used for the treatment of skin disorders; however, it is hydrophobic and has weak penetrating ability, resulting in poor drug transport through the stratum corneum. The aim of this study was to develop liquid crystalline systems for topical administration of curcumin for the treatment of inflammation. These liquid crystalline systems were developed from oleic acid, polyoxypropylene (5) polyoxyethylene (20) cetyl alcohol, and water as the surfactant, oil phase, and aqueous phase, respectively. These systems were characterized, and polarized light microscopy showed anisotropy with lamellar mesophases (Formulation 1) and hexagonal mesophases (Formulations 2 and 3), which were confirmed by the peak ratio measured using small-angle X-ray scattering. In addition, rheological tests revealed that the formulations exhibited gel-like behavior (G'>G ''), as evidenced by the increased G' values that indicate structured systems. Texture profile analysis showed that hexagonal mesophases have high values of hardness, adhesiveness, and compressibility, which indicate structured systems. In vitro studies on bioadhesion revealed that the hexagonal mesophases increased the bioadhesiveness of the systems to the skin of the pig ear. An in vivo inflammation experiment showed that the curcumin-loaded hexagonal mesophase exhibited an anti-inflammatory activity as compared to the positive control (dexamethasone). The results suggest that this system has a potential to be used as a bioadhesive vehicle for the topical administration of curcumin. Therefore, it is possible to conclude that these systems can be used for the optimization of drug delivery systems to the skin.en
dc.description.affiliationUNESP Sao Paulo State Univ, Sch Pharmaceut Sci, Rodovia Araraquara Jau Km 01, BR-14801902 Sao Paulo, Brazil
dc.description.affiliationUnespUNESP Sao Paulo State Univ, Sch Pharmaceut Sci, Rodovia Araraquara Jau Km 01, BR-14801902 Sao Paulo, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipPrograma de Apoio ao Desenvolvimento Cientifico (PADC-FCF-UNESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 13/03746-3
dc.description.sponsorshipIdFAPESP: 15/05394-2
dc.format.extent4553-4562
dc.identifierhttp://dx.doi.org/10.2147/IJN.S108675
dc.identifier.citationInternational Journal Of Nanomedicine. Albany: Dove Medical Press Ltd, v. 11, p. 4553-4562, 2016.
dc.identifier.doi10.2147/IJN.S108675
dc.identifier.issn1178-2013
dc.identifier.lattes1427125996716282
dc.identifier.urihttp://hdl.handle.net/11449/165306
dc.identifier.wosWOS:000383186500003
dc.language.isoeng
dc.publisherDove Medical Press Ltd
dc.relation.ispartofInternational Journal Of Nanomedicine
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectlamellar mesophase
dc.subjecthexagonal mesophase
dc.subjectliquid crystalline mesophase
dc.subjectself-assembly structures
dc.subjectwater-surfactant-oil based-structures
dc.subjectcurcumin
dc.subjectpaw edema
dc.titleDesign, characterization, and biological evaluation of curcumin-loaded surfactant-based systems for topical drug deliveryen
dc.typeArtigo
dcterms.rightsHolderDove Medical Press Ltd
unesp.author.lattes1427125996716282
unesp.author.orcid0000-0002-4259-0008[1]
unesp.author.orcid0000-0002-6698-0545[5]
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Artigos - Fármacos e Medicamentos - FCFAR