Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety

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dc.contributor.authorDedic, Nina
dc.contributor.authorKuehne, Claudia
dc.contributor.authorJakovcevski, Mira
dc.contributor.authorHartmann, Jakob
dc.contributor.authorGenewsky, Andreas J.
dc.contributor.authorGomes, Karina S. [UNESP]
dc.contributor.authorAnderzhanova, Elmira
dc.contributor.authorPoehlmann, Max L.
dc.contributor.authorChang, Simon
dc.contributor.authorKolarz, Adam
dc.contributor.authorVogl, Annette M.
dc.contributor.authorDine, Julien
dc.contributor.authorMetzger, Michael W.
dc.contributor.authorSchmid, Bianca
dc.contributor.authorAlmada, Rafael C.
dc.contributor.authorRessler, Kerry J.
dc.contributor.authorWotjak, Carsten T.
dc.contributor.authorGrinevich, Valery
dc.contributor.authorChen, Alon
dc.contributor.authorSchmidt, Mathias V.
dc.contributor.authorWurst, Wolfgang
dc.contributor.authorRefojo, Damian
dc.contributor.authorDeussing, Jan M.
dc.contributor.institutionMax Planck Inst Psychiat
dc.contributor.institutionHarvard Med Sch
dc.contributor.institutionMcLean Hosp
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionHeidelberg Univ
dc.contributor.institutionHelmholtz Zentrum Munchen
dc.contributor.institutionTech Univ Munich
dc.contributor.institutionGerman Ctr Neurodegenerat Dis DZNE
dc.contributor.institutionMax Planck Gesell
dc.date.accessioned2018-11-26T16:01:21Z
dc.date.available2018-11-26T16:01:21Z
dc.date.issued2018-06-01
dc.description.abstractThe interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release.en
dc.description.affiliationMax Planck Inst Psychiat, Dept Stress Neurobiol & Neurogenet, Munich, Germany
dc.description.affiliationHarvard Med Sch, Dept Psychiat, Belmont, MA USA
dc.description.affiliationMcLean Hosp, 115 Mill St, Belmont, MA 02178 USA
dc.description.affiliationUniv Estadual Paulista, Lab Neuropsychopharmacol, Araraquara, Brazil
dc.description.affiliationHeidelberg Univ, Schaller Res Grp Neuropeptides, German Canc Res Ctr, Cent Inst Mental Hlth, Heidelberg, Germany
dc.description.affiliationHelmholtz Zentrum Munchen, Inst Dev Genet, Munich, Germany
dc.description.affiliationTech Univ Munich, Chair Dev Genet, Munich, Germany
dc.description.affiliationGerman Ctr Neurodegenerat Dis DZNE, Site Munich, Munich, Germany
dc.description.affiliationMax Planck Gesell, Inst Invest Biomed Buenos Aires IBioBA, CONICET, Partner Inst, Buenos Aires, DF, Argentina
dc.description.affiliationUnespUniv Estadual Paulista, Lab Neuropsychopharmacol, Araraquara, Brazil
dc.description.sponsorshipMax Planck Society
dc.description.sponsorshipVolkswagen Foundation
dc.description.sponsorshipGerman Federal Ministry of Education and Research
dc.description.sponsorshipHelmholtz Alliance ICEMED
dc.description.sponsorshipChica and Heinz Schaller Foundation
dc.description.sponsorshipDFG
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdGerman Federal Ministry of Education and Research: 01ZX1314H
dc.description.sponsorshipIdDFG: SFB 1134
dc.description.sponsorshipIdFAPESP: 2013/03445-3
dc.format.extent803-+
dc.identifierhttp://dx.doi.org/10.1038/s41593-018-0151-z
dc.identifier.citationNature Neuroscience. New York: Nature Publishing Group, v. 21, n. 6, p. 803-+, 2018.
dc.identifier.doi10.1038/s41593-018-0151-z
dc.identifier.issn1097-6256
dc.identifier.urihttp://hdl.handle.net/11449/160318
dc.identifier.wosWOS:000433232600008
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofNature Neuroscience
dc.relation.ispartofsjr15,207
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleChronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxietyen
dc.typeArtigo
dcterms.rightsHolderNature Publishing Group
unesp.author.orcid0000-0003-2262-823X[3]
unesp.author.orcid0000-0002-6017-2862[5]

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