Electrospun PHBV nanofiber containing Tea Tree Oil: physicochemical and antimicrobial activity

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dc.contributor.authordos Santos, Verônica Ribeiro
dc.contributor.authorVera, Samara Domingues
dc.contributor.authorde Cena, Gabrielle Lupeti
dc.contributor.authorSilva, Adrielle de Paula
dc.contributor.authorLemes, Ana Paula
dc.contributor.authorda Conceição, Kátia
dc.contributor.authorTada, Dayane Batista
dc.contributor.authorBorges, Alexandre Luiz Souto [UNESP]
dc.contributor.authorTrichês, Eliandra de Sousa
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T13:54:47Z
dc.date.available2023-07-29T13:54:47Z
dc.date.issued2023-01-01
dc.description.abstractAiming to produce an antimicrobial dressing for wound healing applications, in this work Tea Tree oil (TTO) was incorporated into PHBV nanofibers by absorption. It was observed increase in the nanofiber diameter due to 5% TTO absorption efficiency, which also led to a 54% decrease in the contact angle. The releasing assay indicates a 6.8% oil release in the first 24 h – being probably the oil deposited at the polymer surface – followed by a minimal release at 48 h. The set of antimicrobial assays performed suggests the incorporation of TTO optimized the antimicrobial activity of the polymer for E. coli and C. albicans, while against S. aureus no significant difference was observed. The MTT assay showed no cytotoxicity of PHBV, but the incubation of L929 fibroblast cells with PHBV-TTO reduced cell viability. Overall, the PHBV nanofibers containing TTO present great potential as an antimicrobial dressing.en
dc.description.affiliationLaboratório de Biocerâmicas Instituto de Ciência e Tecnologia Universidade Federal de São Paulo – UNIFESP, SP
dc.description.affiliationLaboratório de Bioquímica de Pepitídeos Instituto de Ciência e Tecnologia Universidade Federal de São Paulo – UNIFESP
dc.description.affiliationLaboratório de Nanomateriais e Nanotoxicologia Instituto de Ciência e Tecnologia Universidade Federal de São Paulo – UNIFESP, SP
dc.description.affiliationLaboratório de Tecnologia em Polímeros e Biopolímeros Instituto de Ciência e Tecnologia Universidade Federal de São Paulo – UNIFESP, SP
dc.description.affiliationDepartamento de Materiais Dentários e Prostodontia Instituto de Ciência e Tecnologia Universidade Estadual Paulista – UNESP, SP
dc.description.affiliationUnespDepartamento de Materiais Dentários e Prostodontia Instituto de Ciência e Tecnologia Universidade Estadual Paulista – UNESP, SP
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2019-19594-4
dc.description.sponsorshipIdFAPESP: 2019/10877-3
dc.description.sponsorshipIdFAPESP: 2020/04455-6
dc.identifierhttp://dx.doi.org/10.1590/0104-1428.20220088
dc.identifier.citationPolimeros, v. 33, n. 1, 2023.
dc.identifier.doi10.1590/0104-1428.20220088
dc.identifier.issn1678-5169
dc.identifier.issn0104-1428
dc.identifier.scopus2-s2.0-85159169798
dc.identifier.urihttp://hdl.handle.net/11449/248826
dc.language.isoeng
dc.relation.ispartofPolimeros
dc.sourceScopus
dc.subjectantimicrobial activity
dc.subjectnanofiber
dc.subjectPHBV
dc.subjecttea tree oil
dc.subjectwound healing
dc.titleElectrospun PHBV nanofiber containing Tea Tree Oil: physicochemical and antimicrobial activityen
dc.typeArtigo

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