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Anti-coagulase-negative Staphylococcus activity of ethanolic extracts of propolis from two Brazilian regions and synergism with antimicrobial drugs by the E-test method

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dc.contributor.authorMantovani, R. P. [UNESP]
dc.contributor.authorRall, V. L. M. [UNESP]
dc.contributor.authorBatalha, J. E. N. [UNESP]
dc.contributor.authorFernandes, A. A. H. [UNESP]
dc.contributor.authorFernandes, Junior A. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:51:02Z
dc.date.available2014-05-20T13:51:02Z
dc.date.issued2008-01-01
dc.description.abstractPropolis is a natural resinous substance collected by bees from vegetal sources and its therapeutic properties have been investigated. In this work, we evaluated the inhibitory activity of ethanolic extracts of propolis (EEP) from the Southeast and South of Brazil on coagulase-negative Staphylococcus (CNS) growth as well as the EEP in vitro synergism with antimicrobial drugs by using the diffusion method (E-test). The EEP chemical characteristics (dry weight, pH, flavonoid and phenolic compounds) were determined. Seven drugs were tested, and synergism was observed between three drugs and Southeast EEP, six drugs and South EEP, and one drug and ethanol control. Ethanolic extracts of propolis from the South of Brazil presented the greatest flavonoid content and synergism rate, while EEP from the Southeast presented the greatest anti-CNS activity and phenolic compound content. Results showed the correlation among anti-CNS activity, synergism rate and chemical characteristics of propolis.en
dc.description.affiliationUNESP, São Paulo State Univ, Botucatu Inst Biosci, Dept Microbiol & Immunol, Botucatu, SP, Brazil
dc.description.affiliationUNESP, Dept Chem & Biochem, Botucatu Inst Biosci, Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, São Paulo State Univ, Botucatu Inst Biosci, Dept Microbiol & Immunol, Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Dept Chem & Biochem, Botucatu Inst Biosci, Botucatu, SP, Brazil
dc.format.extent357-365
dc.identifierhttp://dx.doi.org/10.1590/S1678-91992008000200012
dc.identifier.citationJournal of Venomous Animals and Toxins Including Tropical Diseases. Botucatu: Cevap-unesp, v. 14, n. 2, p. 357-365, 2008.
dc.identifier.fileS1678-91992008000200012-en.pdf
dc.identifier.issn1678-9199
dc.identifier.lattes1843683720990222
dc.identifier.scieloS1678-91992008000200012
dc.identifier.urihttp://hdl.handle.net/11449/18221
dc.identifier.wosWOS:000256791100012
dc.language.isoeng
dc.publisherUniversidade Estadual Paulista (Unesp), Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP)
dc.relation.ispartofJournal of Venomous Animals and Toxins Including Tropical Diseases
dc.relation.ispartofjcr1.782
dc.relation.ispartofsjr0,573
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectBrazilian propolisen
dc.subjectcoagulase-negative Staphylococcusen
dc.subjectE-testen
dc.subjectantimicrobial drugsen
dc.subjectsynergismen
dc.titleAnti-coagulase-negative Staphylococcus activity of ethanolic extracts of propolis from two Brazilian regions and synergism with antimicrobial drugs by the E-test methoden
dc.typeResenha
dcterms.licensehttp://www.scielo.br/revistas/jvatitd/iaboutj.htm
dcterms.rightsHolderCevap-unesp
dspace.entity.typePublication
unesp.author.lattes1843683720990222
unesp.author.lattes0077247086732148[4]
unesp.author.orcid0000-0003-4280-5619[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.departmentMicrobiologia e Imunologia - IBBpt
unesp.departmentQuímica e Bioquímica - IBBpt

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