EGFR is not amplified in ameloblastoma

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Costa, Victor [UNESP]
Fregnani, Eduardo Rodrigues
Fonseca, Felipe Paiva
Abreu Alves, Fábio
Pinto, Clóvis Antônio Lopes
Kaminagakura, Estela [UNESP]

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Objective: The aim of this study was to investigate alterations in the EGFR gene and its protein expression for a better understanding of the biologic behavior of ameloblastoma. Study Design: Twenty-five samples of ameloblastoma were selected, and dual-color fluorescence in situ hybridization assay was performed. The results of the assay and immunohistochemistry reaction for EGFR and Ki67 were associated with clinicopathologic features and recurrence. Results: All analyzed cases presented disomy without any gene polysomy or amplification. With regard to EGFR immunoexpression, 3 cases (12%) were considered negative, and 22 (88%) were positive, of which 13 (52%) were weak and 9 (36%) were strong. All samples presented low positivity for Ki67. There was no association between EGFR expression and clinicopathologic features or recurrence (P >.05). In some cases, EGFR immunoexpression was observed without gene amplification. Conclusions: Ameloblastoma development, progression, or recurrence does not appear to be related to EGFR amplification or polysomy.



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Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, v. 125, n. 5, p. 454-458, 2018.