Repercussions of adjuvant-induced arthritis on body composition, soleus muscle, and heart muscle of rats

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dc.contributor.authorPita, L. M.
dc.contributor.authorSpadella, M. A.
dc.contributor.authorMontenote, M. C.
dc.contributor.authorOliveira, P. B.
dc.contributor.authorChies, A. B.
dc.contributor.institutionFaculdade de Medicina de Marília
dc.contributor.institutionInstituto de Biociências de Botucatu
dc.date.accessioned2022-04-29T08:45:26Z
dc.date.available2022-04-29T08:45:26Z
dc.date.issued2020-01-01
dc.description.abstractThis study investigated the repercussions of adjuvant-induced arthritis (AIA) on body composition and the structural organization of the soleus and cardiac muscles, including their vascularization, at different times of disease manifestation. Male rats were submitted to AIA induction by intradermal administration of 100 mL ofMycobacterium tuberculosis (50 mg/mL), in the right hind paw. Animals submitted to AIA were studied 4 (AIA4), 15 (AIA15), and 40 (AIA40) days after AIA induction as well as a control group of animals not submitted to AIA. Unlike the control animals, AIA animals did not gain body mass throughout the evolution of the disease. AIA reduced food consumption, but only on the 40th day after induction. In the soleus muscle, AIA reduced the wet mass in a time-dependent manner but increased the capillary density by the 15th day and the fiber density by both 15 and 40 days after induction. The diameter of the soleus fiber decreased from the 4th day after AIA induction as well as the capillary/fiber ratio, which was most evident on the 40th day. Moreover, AIA induced slight histopathological changes in the cardiac muscle that were more evident on the 15th day after induction. In conclusion, AIA-induced changes in body composition as well as in the soleus muscle fibers and vasculature have early onset but are more evident by the 15th day after induction. Moreover, the heart may be a target organ of AIA, although less sensitive than skeletal muscles.en
dc.description.affiliationLaboratório de Farmacologia Faculdade de Medicina de Marília
dc.description.affiliationLaboratório de Embriologia Humana Faculdade de Medicina de Marília
dc.description.affiliationDepartamento de Farmacologia Instituto de Biociências de Botucatu
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCAPES: 1768591
dc.description.sponsorshipIdFAPESP: 2016/08450-3
dc.description.sponsorshipIdFAPESP: 2017/ 00746-3
dc.identifierhttp://dx.doi.org/10.1590/1414-431x20198969
dc.identifier.citationBrazilian Journal of Medical and Biological Research, v. 53, n. 3, 2020.
dc.identifier.doi10.1590/1414-431x20198969
dc.identifier.issn1678-4510
dc.identifier.issn0100-879X
dc.identifier.scopus2-s2.0-85081042543
dc.identifier.urihttp://hdl.handle.net/11449/231439
dc.language.isoeng
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.sourceScopus
dc.subjectBody composition
dc.subjectCachexia
dc.subjectCardiovascular
dc.subjectExperimental arthritis
dc.subjectMicrocirculation
dc.subjectMusculoskeletal
dc.titleRepercussions of adjuvant-induced arthritis on body composition, soleus muscle, and heart muscle of ratsen
dc.typeArtigo

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