Inside-out vs. standard vein graft to repair a sensory nerve in rats

dc.contributor.authorFerrari, Fábio [UNESP]
dc.contributor.authorDe Rodrigues, Antonio Castro [UNESP]
dc.contributor.authorMalvezzi, Cristiane Karina [UNESP]
dc.contributor.authorSilva, Maeli Dal Pai [UNESP]
dc.contributor.authorPadovani, Carlos Roberto [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:19:47Z
dc.date.available2014-05-27T11:19:47Z
dc.date.issued1999-11-09
dc.description.abstractNerve regeneration in a sensory nerve was obtained by the application of different techniques: inside-out vein graft (IOVG group) and standard vein graft (SVG group). These techniques provide a good microenvironment for axon regeneration in motor nerves, but their efficiency for regeneration of sensory nerves is controversial. The saphenous nerve was sectioned and repaired by the inside-out and standard vein graft techniques in rats. After 4, 12, and 20 weeks the graft and the distal stump were observed under electron microscopy. In each studied period, the pattern, diameters, and thickness of the myelin sheaths of the regenerated axons were measured in the graft and distal stump. A comparative study about the regenerated nerve fibers by these two different techniques was performed. Regenerated nerve fibers were prominent in both vein grafts 4 weeks after the surgical procedures. On the other hand, in the distal stump, regenerated nerve fibers were observed only from 12 weeks. In both inside-out vein graft and standard vein graft statistical difference was not observed about the diameters and thickness of the myelinated fibers after 20 weeks. On the other hand, the inside-out group had greater regenerated axon number when compared to the standard group. There is a capillary invasion in both graft and distal stump, especially in the IOVG group. The regenerated axons follow these capillaries all the time like satellite microfascicles. After 20 weeks, the diameters of regenerated fibers repaired by the standard vein graft technique were closer to the normal fibers compared to the inside-out vein graft. On the other hand, the pattern of these regenerated axons was better in the IOVG group.en
dc.description.affiliationDepartment of Anatomy IB/UNESP/Botucatu, São Paulo
dc.description.affiliationDepartment of Morphology IB/UNESP/Botucatu, São Paulo
dc.description.affiliationDepartment of Biostatistics IB/UNESP/Botucatu, São Paulo
dc.description.affiliationDepartment of Anatomy IB/UNESP/Botucatu, 18618-000 Rubião Júnior, São Paulo
dc.description.affiliationUnespDepartment of Anatomy IB/UNESP/Botucatu, São Paulo
dc.description.affiliationUnespDepartment of Morphology IB/UNESP/Botucatu, São Paulo
dc.description.affiliationUnespDepartment of Biostatistics IB/UNESP/Botucatu, São Paulo
dc.description.affiliationUnespDepartment of Anatomy IB/UNESP/Botucatu, 18618-000 Rubião Júnior, São Paulo
dc.format.extent227-232
dc.identifierhttp://dx.doi.org/10.1002/(SICI)1097-0185(19991101)256:3<227
dc.identifier.citationAnatomical Record, v. 256, n. 3, p. 227-232, 1999.
dc.identifier.doi10.1002/(SICI)1097-0185(19991101)256:3<227
dc.identifier.file2-s2.0-0032702841.pdf
dc.identifier.issn0003-276X
dc.identifier.lattes8727897080522289
dc.identifier.scopus2-s2.0-0032702841
dc.identifier.urihttp://hdl.handle.net/11449/65887
dc.identifier.wosWOS:000083355800002
dc.language.isoeng
dc.relation.ispartofAnatomical Record
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectNerve regeneration
dc.subjectRat
dc.subjectVein graft
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectcapillary proliferation
dc.subjectelectron microscopy
dc.subjectmale
dc.subjectmyelin sheath
dc.subjectnerve fiber regeneration
dc.subjectnerve regeneration
dc.subjectnerve transection
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrat
dc.subjectsaphenous nerve
dc.subjecttechnique
dc.subjectvein graft
dc.subjectvein wall
dc.subjectAnimals
dc.subjectAxons
dc.subjectDisease Models, Animal
dc.subjectImage Processing, Computer-Assisted
dc.subjectJugular Veins
dc.subjectMale
dc.subjectNerve Fibers
dc.subjectNerve Regeneration
dc.subjectPeripheral Nerves
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSaphenous Vein
dc.subjectTransplantation, Autologous
dc.subjectAnimalia
dc.titleInside-out vs. standard vein graft to repair a sensory nerve in ratsen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
unesp.author.lattes8727897080522289[5]
unesp.author.orcid0000-0002-7719-9682[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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