Serotonergic mechanisms of the lateral parabrachial nucleus on DOCA-induced sodium intake
dc.contributor.author | De Gobbi, JIF | |
dc.contributor.author | De Luca, L. A. | |
dc.contributor.author | Menani, José Vanderlei [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2014-05-20T13:45:42Z | |
dc.date.available | 2014-05-20T13:45:42Z | |
dc.date.issued | 2000-10-13 | |
dc.description.abstract | It has been shown that the serotonergic mechanisms of the lateral parabrachial nucleus (LPBN) inhibit NaCl intake in different models of angiotensin II (ANG II)-dependent NaCl intake in rats. However, there is no information about the involvement of LPBN serotonergic mechanisms on NaCl intake in a model of NaCl intake not dependent on ANG II like deoxycorticosterone (DOCA)-induced NaCl intake. Therefore, in this study we investigated the effects of bilateral injections of serotonergic agonist and antagonist into the LPBN on DOCA-induced 1.8% NaCl intake in rats. Male Holtzman rats were treated with s.c. DOCA (10 mg/rat each every 3 days). After a period of training, in which the rats had access to 1.8% NaCI during 2 h for several days, the rats were implanted with stainless steel cannulas bilaterally into the LPBN. Bilateral injections of the serotonergic receptor antagonist methysergide (4 mug/0.2 mul each site) in the LPBN increased 1.8% NaCI intake (32.2+/-3.9 versus vehicle: 15.0+/-1.6 ml/2 h, n = 10) and water intake (11.5+/-3.5 versus vehicle: 3.2+/-1.0 ml/2 h). Injections of the serotonergic 5HT(2A/2C) receptor agonist DOI (5 mug/0,2 mul each site) in the LPBN reduced 1.8% NaCl intake (6.8+/-1.7 versus saline: 12.4+/-1.9 ml/2 h, n = 10) and water intake (2.2+/-0.8 versus saline: 4.4+/-1.0 ml/2 h). Besides the previously demonstrated importance for the control of ANG II-dependent water and NaCl intake, the data show that the serotonergic inhibitory mechanisms of the LPBN are also involved in the control of DOCA-induced NaCl intake. (C) 2000 Elsevier B.V. B.V. All rights reserved. | en |
dc.description.affiliation | Paulista State Univ, UNESP, Sch Dent, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, Brazil | |
dc.description.affiliationUnesp | Paulista State Univ, UNESP, Sch Dent, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, Brazil | |
dc.format.extent | 131-138 | |
dc.identifier | http://dx.doi.org/10.1016/S0006-8993(00)02784-0 | |
dc.identifier.citation | Brain Research. Amsterdam: Elsevier B.V., v. 880, n. 1-2, p. 131-138, 2000. | |
dc.identifier.doi | 10.1016/S0006-8993(00)02784-0 | |
dc.identifier.issn | 0006-8993 | |
dc.identifier.lattes | 1023597870118105 | |
dc.identifier.uri | http://hdl.handle.net/11449/16092 | |
dc.identifier.wos | WOS:000089955600014 | |
dc.language.iso | eng | |
dc.publisher | Elsevier B.V. | |
dc.relation.ispartof | Brain Research | |
dc.relation.ispartofjcr | 3.125 | |
dc.relation.ispartofsjr | 1,404 | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | deoxycorticosterone | pt |
dc.subject | NaCl intake | pt |
dc.subject | water intake | pt |
dc.subject | 5HT | pt |
dc.subject | LPBN | pt |
dc.title | Serotonergic mechanisms of the lateral parabrachial nucleus on DOCA-induced sodium intake | en |
dc.type | Artigo | |
dcterms.license | http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy | |
dcterms.rightsHolder | Elsevier B.V. | |
unesp.author.lattes | 1023597870118105 | |
unesp.author.orcid | 0000-0001-8270-2652[2] | |
unesp.author.orcid | 0000-0001-5845-0475[1] | |
unesp.author.orcid | 0000-0003-1167-4441[3] | |
unesp.campus | Universidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquara | pt |
unesp.department | Fisiologia e Patologia - FOAR | pt |
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