Serotonergic mechanisms of the lateral parabrachial nucleus on DOCA-induced sodium intake

dc.contributor.authorDe Gobbi, JIF
dc.contributor.authorDe Luca, L. A.
dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:45:42Z
dc.date.available2014-05-20T13:45:42Z
dc.date.issued2000-10-13
dc.description.abstractIt has been shown that the serotonergic mechanisms of the lateral parabrachial nucleus (LPBN) inhibit NaCl intake in different models of angiotensin II (ANG II)-dependent NaCl intake in rats. However, there is no information about the involvement of LPBN serotonergic mechanisms on NaCl intake in a model of NaCl intake not dependent on ANG II like deoxycorticosterone (DOCA)-induced NaCl intake. Therefore, in this study we investigated the effects of bilateral injections of serotonergic agonist and antagonist into the LPBN on DOCA-induced 1.8% NaCl intake in rats. Male Holtzman rats were treated with s.c. DOCA (10 mg/rat each every 3 days). After a period of training, in which the rats had access to 1.8% NaCI during 2 h for several days, the rats were implanted with stainless steel cannulas bilaterally into the LPBN. Bilateral injections of the serotonergic receptor antagonist methysergide (4 mug/0.2 mul each site) in the LPBN increased 1.8% NaCI intake (32.2+/-3.9 versus vehicle: 15.0+/-1.6 ml/2 h, n = 10) and water intake (11.5+/-3.5 versus vehicle: 3.2+/-1.0 ml/2 h). Injections of the serotonergic 5HT(2A/2C) receptor agonist DOI (5 mug/0,2 mul each site) in the LPBN reduced 1.8% NaCl intake (6.8+/-1.7 versus saline: 12.4+/-1.9 ml/2 h, n = 10) and water intake (2.2+/-0.8 versus saline: 4.4+/-1.0 ml/2 h). Besides the previously demonstrated importance for the control of ANG II-dependent water and NaCl intake, the data show that the serotonergic inhibitory mechanisms of the LPBN are also involved in the control of DOCA-induced NaCl intake. (C) 2000 Elsevier B.V. B.V. All rights reserved.en
dc.description.affiliationPaulista State Univ, UNESP, Sch Dent, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUnespPaulista State Univ, UNESP, Sch Dent, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, Brazil
dc.format.extent131-138
dc.identifierhttp://dx.doi.org/10.1016/S0006-8993(00)02784-0
dc.identifier.citationBrain Research. Amsterdam: Elsevier B.V., v. 880, n. 1-2, p. 131-138, 2000.
dc.identifier.doi10.1016/S0006-8993(00)02784-0
dc.identifier.issn0006-8993
dc.identifier.lattes1023597870118105
dc.identifier.urihttp://hdl.handle.net/11449/16092
dc.identifier.wosWOS:000089955600014
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Research
dc.relation.ispartofjcr3.125
dc.relation.ispartofsjr1,404
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectdeoxycorticosteronept
dc.subjectNaCl intakept
dc.subjectwater intakept
dc.subject5HTpt
dc.subjectLPBNpt
dc.titleSerotonergic mechanisms of the lateral parabrachial nucleus on DOCA-induced sodium intakeen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes1023597870118105
unesp.author.orcid0000-0001-8270-2652[2]
unesp.author.orcid0000-0001-5845-0475[1]
unesp.author.orcid0000-0003-1167-4441[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt
unesp.departmentFisiologia e Patologia - FOARpt

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