Morphological and metabolic determinants of nonalcoholic fatty liver disease in obese youth: a pilot study.

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dc.contributor.authorMonteiro, Paula A [UNESP]
dc.contributor.authorMota, Jorge
dc.contributor.authorSilveira, Loreana S
dc.contributor.authorCayres, Suziane U
dc.contributor.authorAntunes, Bárbara de Moura M
dc.contributor.authorFernandes, Romulo Araujo
dc.contributor.authorFreitas Jr., Ismael F
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-29T06:48:24Z
dc.date.available2022-04-29T06:48:24Z
dc.date.issued2013-01-01
dc.description.abstractNonalcoholic fatty liver disease (NAFLD) related to obesity has been rising in the last decades, though the morphological and metabolic determinants are remain unclear in children. The aim of this study was to analyze the morphological determinants and metabolic abnormalities in obese children and adolescents, classified either as with (P-NAFLD) or without (N-NAFLD). The sample comprised 190 individuals, aged 6 to 16 years-old, assigned into one of 4 groups according to sex and presence or absence of NAFLD. Obesity was obtained according to body mass index (BMI) cut-points. Body composition variables was estimated by Dual-Energy X-ray Absorptiometry (DEXA). Total cholesterol (TC), triglycerides (TG), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), insulin, fasting glucose (FG) and blood pressure were also analyzed. The diagnosis of NAFLD, as well as the measurement of intra-abdominal fat tissue thickness (IAF) and subcutaneous abdominal fat tissue thickness (SCF), was carried-out by ultrasound. Males and females belonging to P-NAFLD group showed, respectively, higher TFM and IAF. When data were adjusted for sex, age and total fat mass, those in P-NAFLD showed statistically higher IAF, TFM and TG. Our study showed that obese youngsters who were assigned to P-NAFLD group were twice as likely to present higher concentration of triglycerides, higher levels of trunk fat, as well as intra-abdominal fat compared to their N-NAFLD counterparts even after adjustments for sex, age, pubertal stage and total body fat mass.en
dc.description.affiliationRedentore Gonfiantine St. Vila São Francisco Department of Physiotherapy University Estadual Paulista Campus of Presidente Prudente, São Paulo Zip code 05351020
dc.description.affiliationUnespRedentore Gonfiantine St. Vila São Francisco Department of Physiotherapy University Estadual Paulista Campus of Presidente Prudente, São Paulo Zip code 05351020
dc.format.extent89
dc.identifierhttp://dx.doi.org/10.1186/1756-0500-6-89
dc.identifier.citationBMC research notes, v. 6, p. 89-.
dc.identifier.doi10.1186/1756-0500-6-89
dc.identifier.issn1756-0500
dc.identifier.scopus2-s2.0-84874736363
dc.identifier.urihttp://hdl.handle.net/11449/227136
dc.language.isoeng
dc.relation.ispartofBMC research notes
dc.sourceScopus
dc.titleMorphological and metabolic determinants of nonalcoholic fatty liver disease in obese youth: a pilot study.en
dc.typeArtigo

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