Behind Base J: The Roles of JBP1 and JBP2 on Trypanosomatids

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dc.contributor.authorAssis, Luiz Henrique de Castro [UNESP]
dc.contributor.authorde Paiva, Stephany Cacete [UNESP]
dc.contributor.authorCano, Maria Isabel Nogueira [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T16:09:51Z
dc.date.available2023-07-29T16:09:51Z
dc.date.issued2023-03-01
dc.description.abstractβ-D-glucopyranosyloxymethiluracil (Base J) is a modified thymidine base found in kinetoplastids and some related organisms. Interestingly, Base J distribution into the genome can vary depending on the organism and its life stage. Base J is reported to be found mostly at telomeric repeats, on inactive variant surface glycoproteins (VSG’s) expression sites (e.g., T. brucei), in RNA polymerase II termination sites and sub-telomeric regions (e.g., Leishmania). This hypermodified nucleotide is synthesized in two steps with the participation of two distinct thymidine hydroxylases, J-binding protein 1 and 2 (JBP1 and JBP2, respectively) and a β-glucosyl transferase. A third J-binding protein, named JBP3, was recently identified as part of a multimeric complex. Although its structural similarities with JBP1, it seems not to be involved in J biosynthesis but to play roles in gene expression regulation in trypanosomatids. Over the years, with the characterization of JBP1 and JBP2 mutant lines, Base J functions have been targeted and shone a light on that matter, showing genus-specific features. This review aims to explore Base J’s reported participation as a regulator of RNA polymerase II transcription termination and to summarize the functional and structural characteristics and similarities of the remarkable JBP proteins in pathogenic trypanosomatids.en
dc.description.affiliationTelomeres Laboratory Department of Chemical and Biological Sciences Biosciences Institute São Paulo State University (UNESP), SP
dc.description.affiliationUnespTelomeres Laboratory Department of Chemical and Biological Sciences Biosciences Institute São Paulo State University (UNESP), SP
dc.identifierhttp://dx.doi.org/10.3390/pathogens12030467
dc.identifier.citationPathogens, v. 12, n. 3, 2023.
dc.identifier.doi10.3390/pathogens12030467
dc.identifier.issn2076-0817
dc.identifier.scopus2-s2.0-85151439800
dc.identifier.urihttp://hdl.handle.net/11449/249813
dc.language.isoeng
dc.relation.ispartofPathogens
dc.sourceScopus
dc.subjectBase J
dc.subjectJ-binding proteins
dc.subjecttrypanosomatids
dc.titleBehind Base J: The Roles of JBP1 and JBP2 on Trypanosomatidsen
dc.typeResenha
unesp.author.orcid0000-0002-0907-3076[1]
unesp.author.orcid0000-0003-1554-6826[2]
unesp.author.orcid0000-0001-9798-6627[3]

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