(A)symmetry during gait initiation in people with Parkinson’s disease: A motor and cortical activity exploratory study

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dc.contributor.authorFaria, Murilo Henrique [UNESP]
dc.contributor.authorSimieli, Lucas [UNESP]
dc.contributor.authorRietdyk, Shirley
dc.contributor.authorPenedo, Tiago [UNESP]
dc.contributor.authorSantinelli, Felipe Balistieri [UNESP]
dc.contributor.authorBarbieri, Fabio Augusto [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionPurdue University
dc.contributor.institutionHasselt University
dc.date.accessioned2023-07-29T16:13:32Z
dc.date.available2023-07-29T16:13:32Z
dc.date.issued2023-01-01
dc.description.abstractBackground: Gait asymmetry and deficits in gait initiation (GI) are among the most disabling symptoms in people with Parkinson’s disease (PwPD). Understanding if PwPD with reduced asymmetry during GI have higher asymmetry in cortical activity may provide support for an adaptive mechanism to improve GI, particularly in the presence of an obstacle. Objective: This study quantified the asymmetry of anticipatory postural adjustments (APAs), stepping parameters and cortical activity during GI, and tested if the presence of an obstacle regulates asymmetry in PwPD. Methods: Sixteen PwPD and 16 control group (CG) performed 20-trials in two conditions: unobstructed and obstructed GI with right and left limbs. We measured, through symmetry index, (i) motor parameters: APAs and stepping, and (ii) cortical activity: the PSD of the frontal, sensorimotor and occipital areas during APA, STEP-I (moment of heel-off of the leading foot in the GI until the heel contact of the same foot); and STEP-II (moment of the heel-off of the trailing foot in the GI until the heel contact of the same foot) phases. Results: Parkinson’s disease showed higher asymmetry in cortical activity during APA, STEP-I and STEP-II phases and step velocity (STEP-II phase) during unobstructed GI than CG. However, unexpectedly, PwPD reduced the level of asymmetry of anterior–posterior displacement (p < 0.01) and medial-lateral velocity (p < 0.05) of the APAs. Also, when an obstacle was in place, PwPD showed higher APAs asymmetry (medial-lateral velocity: p < 0.002), with reduced and increased asymmetry of the cortical activity during APA and STEP-I phases, respectively. Conclusion: Parkinson’s disease were not motor asymmetric during GI, indicating that higher cortical activity asymmetry can be interpreted as an adaptive behavior to reduce motor asymmetry. In addition, the presence of obstacle did not regulate motor asymmetry during GI in PwPD.en
dc.description.affiliationHuman Movement Research Laboratory (MOVI-LAB) School of Sciences Department of Physical Education São Paulo State University (Unesp), São Paulo
dc.description.affiliationDepartment of Health and Kinesiology Purdue University
dc.description.affiliationREVAL Rehabilitation Research Center Faculty of Rehabilitation Sciences Hasselt University
dc.description.affiliationUnespHuman Movement Research Laboratory (MOVI-LAB) School of Sciences Department of Physical Education São Paulo State University (Unesp), São Paulo
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: #2016/14950–6
dc.description.sponsorshipIdFAPESP: #2018/21870–7
dc.description.sponsorshipIdFAPESP: #2019/24752–8
dc.identifierhttp://dx.doi.org/10.3389/fnagi.2023.1142540
dc.identifier.citationFrontiers in Aging Neuroscience, v. 15.
dc.identifier.doi10.3389/fnagi.2023.1142540
dc.identifier.issn1663-4365
dc.identifier.scopus2-s2.0-85159003673
dc.identifier.urihttp://hdl.handle.net/11449/249944
dc.language.isoeng
dc.relation.ispartofFrontiers in Aging Neuroscience
dc.sourceScopus
dc.subjectasymmetry
dc.subjectcortical activity
dc.subjectgait initiation
dc.subjectobstacle avoidance
dc.subjectParkinson’s disease
dc.title(A)symmetry during gait initiation in people with Parkinson’s disease: A motor and cortical activity exploratory studyen
dc.typeArtigo
unesp.departmentEducação Física - FCpt

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