Biomaterial engineering surface to control polymicrobial dental implant-related infections: focusing on disease modulating factors and coatings development

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dc.contributor.authorMalheiros, Samuel S.
dc.contributor.authorNagay, Bruna E.
dc.contributor.authorBertolini, Martinna M.
dc.contributor.authorde Avila, Erica D. [UNESP]
dc.contributor.authorShibli, Jamil A.
dc.contributor.authorSouza, João Gabriel S.
dc.contributor.authorBarão, Valentim A. R.
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversity of Pittsburgh
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionGuarulhos University
dc.contributor.institutionDental Science School (Faculdade de Ciências Odontológicas - FCO)
dc.date.accessioned2023-07-29T13:57:51Z
dc.date.available2023-07-29T13:57:51Z
dc.date.issued2023-01-01
dc.description.abstractIntroduction: Peri-implantitis is the leading cause of dental implant loss and is initiated by a polymicrobial dysbiotic biofilm formation on the implant surface. The destruction of peri-implant tissue by the host immune response and the low effectiveness of surgical or non-surgical treatments highlight the need for new strategies to prevent, modulate and/or eliminate biofilm formation on the implant surface. Currently, several surface modifications have been proposed using biomolecules, ions, antimicrobial agents, and topography alterations. Areas covered: Initially, this review provides an overview of the etiopathogenesis and host- and material-dependent modulating factors of peri-implant disease. In addition, a critical discussion about the antimicrobial surface modification mechanisms and techniques employed to modify the titanium implant material is provided. Finally, we also considered the future perspectives on the development of antimicrobial surfaces to narrow the bridge between idea and product and favor the clinical application possibility. Expert opinion: Antimicrobial surface modifications have demonstrated effective results; however, there is no consensus about the best modification strategy and in-depth information on the safety and longevity of the antimicrobial effect. Modified surfaces display recurring challenges such as short-term effectiveness, the burst release of drugs, cytotoxicity, and lack of reusability. Stimulus-responsive surfaces seem to be a promising strategy for a controlled and precise antimicrobial effect, and future research should focus on this technology and study it from models that better mimic clinical conditions.en
dc.description.affiliationDepartment of Prosthodontics and Periodontology Piracicaba Dental School University of Campinas (UNICAMP), São Paulo
dc.description.affiliationDepartment of Periodontics and Preventive Dentistry School of Dental Medicine University of Pittsburgh
dc.description.affiliationDepartment of Dental Materials and Prosthodontics School of Dentistry at Araçatuba São Paulo State University (UNESP), Sao Paulo
dc.description.affiliationDental Research Division Guarulhos University, São Paulo
dc.description.affiliationDental Science School (Faculdade de Ciências Odontológicas - FCO), Minas Gerais
dc.description.affiliationUnespDepartment of Dental Materials and Prosthodontics School of Dentistry at Araçatuba São Paulo State University (UNESP), Sao Paulo
dc.identifierhttp://dx.doi.org/10.1080/17434440.2023.2218547
dc.identifier.citationExpert Review of Medical Devices.
dc.identifier.doi10.1080/17434440.2023.2218547
dc.identifier.issn1745-2422
dc.identifier.issn1743-4440
dc.identifier.scopus2-s2.0-85161036036
dc.identifier.urihttp://hdl.handle.net/11449/248937
dc.language.isoeng
dc.relation.ispartofExpert Review of Medical Devices
dc.sourceScopus
dc.subjectantimicrobial agents
dc.subjectbiofilm
dc.subjectdental implants
dc.subjectperi-implantitis
dc.subjectsurface properties
dc.subjecttitanium
dc.titleBiomaterial engineering surface to control polymicrobial dental implant-related infections: focusing on disease modulating factors and coatings developmenten
dc.typeResenha

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Artigos - Materiais Odontológicos e Prótese - FOA