The role of oxidative stress in renal injury related to obesity
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Undergraduate course
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Article
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Acesso aberto
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Abstract
The mechanisms linking obesity to kidney damage are unknown. AGEs are responsible for renal damage in obese individuals. The receptor AGEs (RAGE) contributes to nuclear transcription factors that result in the production of proinflammatory cytokines and this seems to contribute to the development of renal disease. Thus, intervention with antioxidant can have an important effect in the prevention and treatment of pro-oxidant and pro-inflammatory state in the kidneys resulting from obesity.
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Keywords
Obesity, Kidney, Oxidative stress, AGEs, RAGE, Inflammatory markers
Language
English
Citation
Inflammation & Cell Signaling, v. 2, p. 1-4, 2015.
