Sistemas para liberação colônica: Uma alternativa para a veiculação de fármacos para efeito local ou sistêmico
Carregando...
Data
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Tipo
Artigo
Direito de acesso
Acesso restrito
Resumo
Problems related to the systemic administration of drugs, such as biodistribution, difficulty of targeting, necessity of high doses to achieve adequate levels of the drug in specific sites, toxicity, and undesirable side effects have lead to the development of systems able to direct the drug to specific sites in the body. Among the possible organs to the targeting of drugs, the colon can be used for local and systemic therapies. By developing such systems some models have been tested, using pH dependent release, release controlled by enzymatic degradation, time controlled release systems and pressure controlled release systems. This review presents an overview of the colonic release of drugs and the strategies used to achieve such targeting.
Descrição
Palavras-chave
Colonic release , Drug controlled release systems , Drug targeting , amylase , beta galactosidase , beta glucosidase , eudragit , glycosidase , mesalazine , olsalazine , polygalacturonase , salazosulfapyridine , xylan 1,4 beta xylosidase , xylan endo 1,3 beta xylosidase , chronic inflammation , colon absorption , controlled drug release , drug binding site , drug delivery system , drug distribution , drug megadose , drug release , drug specificity , drug targeting , enteritis , enzyme degradation , human , pH , pressure measurement , side effect
Idioma
Português
Citação
Revista de Ciencias Farmaceuticas, v. 22, n. 1, p. 11-28, 2001.
Itens relacionados
Financiadores
Outras formas de acesso
