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Evaluation of argyrophilic nucleolar organizer regions in oral tumor progression

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dc.contributor.authorSpolidorio, L. C. [UNESP]
dc.contributor.authorNeves, K. A.
dc.contributor.authorSoares, C. P.
dc.contributor.authorSpolidorio, D. M. P.
dc.contributor.authorBasso, M. F. M.
dc.contributor.authorMalavazzi, I.
dc.contributor.authorAlmeida, O. P.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2015-12-07T15:29:38Z
dc.date.available2015-12-07T15:29:38Z
dc.date.issued2002
dc.description.abstractThe aim of this study was to compare the presence of nucleolar organizer regions (NORs) in normal oral mucosa, dysplasia and microinvasive carcinoma. All histological specimens were reviewed according to the modified classification and staging system for oral leukoplakia described by van-der-Waal et al. [Oral Oncol. 36 (2000) 264]. NOR quantification was performed with an image analyzer after staining by the argyrophilic nucleolar region technique. The morphometric results were statistically different for normal mucosa, dysplasia and microinvasive carcinoma. It was concluded that an increase of NOR activity follows the disease progression and may reflect the degree of cellular proliferation and malignancy.en
dc.description.affiliationDepartment of Oral Pathology, Araraquara Dental School, University of São Paulo State, Rua Humaitá, 1680 CEP, 14801-903 Araraquara, Brazil
dc.description.affiliationDepartment of Clinical Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo State, Rua Expedicionários do Brasil, 1621 CEP, 14801-902 Araraquara, Brazil
dc.description.affiliationDepartment of Oral Pathology, Piracicaba Dental School, UNICAMP, Av Limeira s/n, Piracicaba, Brazil.
dc.description.affiliationUnespDepartment of Oral Pathology, Araraquara Dental School, University of São Paulo State, Rua Humaitá, 1680 CEP, 14801-903 Araraquara, Brazil
dc.description.affiliationUnespDepartment of Clinical Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo State, Rua Expedicionários do Brasil, 1621 CEP, 14801-902 Araraquara, Brazil.
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent605-608
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/12475557
dc.identifier.citationMicron (oxford, England : 1993), v. 33, n. 7-8, p. 605-608, 2002.
dc.identifier.issn0968-4328
dc.identifier.lattes2640929291808415
dc.identifier.pubmed12475557
dc.identifier.urihttp://hdl.handle.net/11449/130829
dc.language.isoeng
dc.publisherElsevier B. V.
dc.relation.ispartofMicron (oxford, England : 1993)
dc.relation.ispartofjcr1.728
dc.relation.ispartofsjr0,624
dc.rights.accessRightsAcesso restritopt
dc.sourcePubMed
dc.subjectArgyrophilic nucleolar regionsen
dc.subjectOral mucosaen
dc.subjectDysplasiaen
dc.subjectOral carcinomaen
dc.subjectTumor progressionen
dc.titleEvaluation of argyrophilic nucleolar organizer regions in oral tumor progressionen
dc.typeArtigopt
dcterms.rightsHolderElsevier B. V.
dspace.entity.typePublication
relation.isDepartmentOfPublicationa83d26d6-5383-42e4-bb3c-2678a6ddc144
relation.isDepartmentOfPublicationb3ba3d9c-022e-4521-8805-0bcceea7372e
relation.isDepartmentOfPublication.latestForDiscoverya83d26d6-5383-42e4-bb3c-2678a6ddc144
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unesp.author.lattes2640929291808415
unesp.author.orcid0000-0003-2376-1024[4]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquarapt
unesp.departmentAnálises Clínicas - FCFpt
unesp.departmentFisiologia e Patologia - FOARpt

Arquivos

Coleções

Araraquara - FOAR - Faculdade de Odontologia
Araraquara - FCF - Faculdade de Ciências Farmacêuticas