Evaluation of argyrophilic nucleolar organizer regions in oral tumor progression
Loading...
Files
External sources
External sources
Date
Advisor
Coadvisor
Graduate program
Undergraduate course
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier B. V.
Type
Article
Access right
Acesso restrito
Files
External sources
External sources
Abstract
The aim of this study was to compare the presence of nucleolar organizer regions (NORs) in normal oral mucosa, dysplasia and microinvasive carcinoma. All histological specimens were reviewed according to the modified classification and staging system for oral leukoplakia described by van-der-Waal et al. [Oral Oncol. 36 (2000) 264]. NOR quantification was performed with an image analyzer after staining by the argyrophilic nucleolar region technique. The morphometric results were statistically different for normal mucosa, dysplasia and microinvasive carcinoma. It was concluded that an increase of NOR activity follows the disease progression and may reflect the degree of cellular proliferation and malignancy.
Description
Keywords
Argyrophilic nucleolar regions, Oral mucosa, Dysplasia, Oral carcinoma, Tumor progression
Language
English
Citation
Micron (oxford, England : 1993), v. 33, n. 7-8, p. 605-608, 2002.
