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Paracoccidioides brasiliensis 14-3-3 protein is important for virulence in a murine model

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dc.contributor.authorMarcos, Caroline Maria [UNESP]
dc.contributor.authorde Oliveira, Haroldo Cesar [UNESP]
dc.contributor.authorAssato, Patricia Akemi [UNESP]
dc.contributor.authorde Andrade, Cleverton Roberto [UNESP]
dc.contributor.authorFusco-Almeida, Ana Marisa [UNESP]
dc.contributor.authorMendes-Giannini, Maria José Soares [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-06T16:47:22Z
dc.date.available2019-10-06T16:47:22Z
dc.date.issued2019-10-01
dc.description.abstractThe Paracoccidioides brasiliensis strain downregulated the expression of adhesin Pb14-3-3 (Pb14-3-3 aRNA) was evaluated in a murine model of paracoccidioidomycosis (PCM). Pb14-3-3 aRNA displays attenuated virulence and triggered the formation of fewer granulomas by lowering the fungal burden in the lungs. Additionally, the Pb14-3-3 aRNA showed more elongated yeast cells and less ability to induce pneumocytes apoptosis in vitro. Our results show that 14-3-3 is an important virulence factor in P. brasiliensis-induced pulmonary infection.en
dc.description.affiliationUniversidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas Departamento de Análises Clínicas Laboratório de Micologia Clinica, Campus Araraquara
dc.description.affiliationUniversidade Estadual Paulista (UNESP) Faculdade de Odontologia de Araraquara Departamento de Fisiologia e Patologia
dc.description.affiliationUnespUniversidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas Departamento de Análises Clínicas Laboratório de Micologia Clinica, Campus Araraquara
dc.description.affiliationUnespUniversidade Estadual Paulista (UNESP) Faculdade de Odontologia de Araraquara Departamento de Fisiologia e Patologia
dc.format.extent900-904
dc.identifierhttp://dx.doi.org/10.1093/mmy/myy112
dc.identifier.citationMedical mycology, v. 57, n. 7, p. 900-904, 2019.
dc.identifier.doi10.1093/mmy/myy112
dc.identifier.issn1460-2709
dc.identifier.lattes2402682969776875
dc.identifier.orcid0000-0001-7015-7175
dc.identifier.scopus2-s2.0-85072148051
dc.identifier.urihttp://hdl.handle.net/11449/189646
dc.language.isoeng
dc.relation.ispartofMedical mycology
dc.rights.accessRightsAcesso abertopt
dc.sourceScopus
dc.subjectParacoccidioides brasiliensis: 14-3-3 protein
dc.subjectpneumocytes apoptosis
dc.subjectvirulence in murine model
dc.titleParacoccidioides brasiliensis 14-3-3 protein is important for virulence in a murine modelen
dc.typeArtigopt
dspace.entity.typePublication
relation.isDepartmentOfPublicationa83d26d6-5383-42e4-bb3c-2678a6ddc144
relation.isDepartmentOfPublicationb3ba3d9c-022e-4521-8805-0bcceea7372e
relation.isDepartmentOfPublication.latestForDiscoverya83d26d6-5383-42e4-bb3c-2678a6ddc144
relation.isOrgUnitOfPublicationca4c0298-cd82-48ee-a9c8-c97704bac2b0
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unesp.author.lattes3716273524139678[5]
unesp.author.lattes2402682969776875[4]
unesp.author.orcid0000-0002-2115-8988[5]
unesp.author.orcid0000-0001-7015-7175[4]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquarapt
unesp.departmentAnálises Clínicas - FCFpt
unesp.departmentFisiologia e Patologia - FOARpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas
Araraquara - FOAR - Faculdade de Odontologia