Paracoccidioides brasiliensis 14-3-3 protein is important for virulence in a murine model
Carregando...
Arquivos
Fontes externas
Fontes externas
Data
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Tipo
Artigo
Direito de acesso
Acesso aberto
Arquivos
Fontes externas
Fontes externas
Resumo
The Paracoccidioides brasiliensis strain downregulated the expression of adhesin Pb14-3-3 (Pb14-3-3 aRNA) was evaluated in a murine model of paracoccidioidomycosis (PCM). Pb14-3-3 aRNA displays attenuated virulence and triggered the formation of fewer granulomas by lowering the fungal burden in the lungs. Additionally, the Pb14-3-3 aRNA showed more elongated yeast cells and less ability to induce pneumocytes apoptosis in vitro. Our results show that 14-3-3 is an important virulence factor in P. brasiliensis-induced pulmonary infection.
Descrição
Palavras-chave
Paracoccidioides brasiliensis: 14-3-3 protein, pneumocytes apoptosis, virulence in murine model
Idioma
Inglês
Citação
Medical mycology, v. 57, n. 7, p. 900-904, 2019.
