Nanotechnology-based drug delivery systems for treatment of hyperproliferative skin diseases - a review
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Bentham Science Publishers
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The chronic hyperproliferative diseases (CHD) include cancer, precancerous lesions and diseases of unknown etiology such as psoriasis. Various drugs have been used in the treatment of CHD, such as antiproliferative and corticosteroids in general. However, some drugs have properties that limit their effectiveness, such as low solubility in water and low penetration of the skin. Thus, the control of drug release in the skin may improve efficacy and reduce side effects of many drugs used in hyperproliferative diseases. The purpose of this study was to make a systematic review of nanotechnology-based drug delivery systems used against hyperproliferative skin diseases. © 2013 Bentham Science Publishers.
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Chronic hyperoproliferative diseases Drug delivery systems Nanotechnology Psoriasis Skin cancer Skin diseases Skin treatment Anti-proliferative Drug delivery system Drug release Skin cancers Skin disease Solubility in waters Systematic Review Dermatology Disease control Drug delivery Drug interactions Drug products Diseases aminolevulinic acid benzopsoralen 3 ethoxy carbonyl 2h benzofuro[3,2 e] 1 benzopiran 2 one chitosan derivative clobetasol propionate corticosteroid etretin fluorouracil glycerol behenate ketoprofen methotrexate methoxsalen n sulfonate n,o carboxymethylchitosan nanocapsule nanocoating paclitaxel phosphatidylcholine podophyllotoxin poloxamer polymer polymeric nanoparticle polymethacrylic acid psoralen derivative retinoic acid solid lipid nanoparticle spantide tacrolimus temoporfin triamcinolone acetonide unclassified drug biodegradability burning sensation cell differentiation cell viability chronic hyperproliferative disease contact dermatitis cream dermatitis drug absorption drug cytotoxicity drug delivery system drug efficacy drug penetration drug release drug retention drug safety drug solubility encapsulation erythema human injection site pruritus iontophoresis keratinocyte liquid crystal microemulsion nanomedicine nanotechnology photochemotherapy photodynamic therapy photosensitivity precancer priority journal psoriasis PUVA skin allergy skin cancer skin disease skin infection skin penetration skin tumor stratum corneum systematic review T lymphocyte topical treatment ultraviolet A radiation ultraviolet B radiation
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Current Nanoscience, v. 9, n. 1, p. 159-167, 2013.
